公开(公告)号：EP2326327B1

公开(公告)日：2016-03-23

申请号：EP09814892.7

申请日：2009-09-17

申请人： SRI International

发明人： JONG, Ling ,  JIANG, Faming ,  LI, Gaoquan ,  MORTELMANS, Kristien

IPC分类号： A61K31/407 ,  A61P31/04 ,  A61K31/404 ,  C07D487/04

CPC分类号： A61K31/407 ,  A61K31/445 ,  A61K31/497 ,  A61K31/535 ,  A61K31/551 ,  C07D487/04 ,  Y02A50/475 ,  Y02A50/481

摘要： Compounds useful as antibacterial agents are provided. The compounds are analogs of indole-3-carbinol and have a backbone selected from dihydroindolo[2,3-b]carbazole, 2,2′-diindolylmethane, 2′,3-diindolylmethane, and 3,3′-diindolylmethane. The compounds are useful therapeutic and prophylactic treatment of bacterial infections in mammals. Methods of synthesis of the compounds are provided, as are pharmaceutical compositions containing the compounds.

公开(公告)号：EP2326327A2

公开(公告)日：2011-06-01

申请号：EP09814892.7

申请日：2009-09-17

申请人： SRI International

发明人： JONG, Ling ,  JIANG, Faming ,  LI, Gaoquan ,  MORTELMANS, Kristien

IPC分类号： A61K31/407 ,  A61P31/04 ,  A61K31/404

CPC分类号： A61K31/407 ,  A61K31/445 ,  A61K31/497 ,  A61K31/535 ,  A61K31/551 ,  C07D487/04 ,  Y02A50/475 ,  Y02A50/481

摘要： Compounds useful as antibacterial agents are provided. The compounds are analogs of indole-3-carbinol and have a backbone selected from dihydroindolo[2,3-b]carbazole, 2,2′-diindolylmethane, 2′,3-diindolylmethane, and 3,3′-diindolylmethane. The compounds are useful therapeutic and prophylactic treatment of bacterial infections in mammals. Methods of synthesis of the compounds are provided, as are pharmaceutical compositions containing the compounds.