公开(公告)号：EP1656552A1

公开(公告)日：2006-05-17

申请号：EP04753441.7

申请日：2004-06-14

申请人： STABLE SOLUTIONS, INC. ,  Nicoli, David F. ,  DRISCOLL, David F. ,  BISTRIAN, Bruce R.

发明人： NICOLI, David, F. ,  DRISCOLL, David, F. ,  BISTRIAN, Bruce, R.

IPC分类号： G01N33/00

CPC分类号： G01N33/03 ,  G01N15/1456 ,  G01N21/532 ,  G01N2015/0092 ,  G01N2015/1493 ,  G01N2203/0025 ,  Y10T436/2525

摘要： A method and apparatus for determining the stability of dispersions and emulsions (100, 10N) accelerates the onset of significant particle agglomeration in a sample by stressing the sample by reducing the height of the interparticle potential energy barrier between the particles. This is achieved by adding one or more of three stress factors (111, 11N): changing the pH of the sample to reduce the surface charge on the particles; adding an adsorbing electrolyte so that ions of the appropriate charge are adsorbed onto the surfaces of the particles to reduce the net charge on the particles; and applying a monovalent, divalent, or trivalent salt to partially screen electrostatic repulsions between the charged particles. In a preferred embodiment, the increase in agglomeration is detected with single particle detection, such as SPOS, to generate a PSD (12) from which a figure of merit (16) is derived. Another embodiment detects turbidity or light scattering to generate a value X indicative of the extent of agglomeration.

公开(公告)号：EP1656552B1

公开(公告)日：2014-03-26

申请号：EP04753441.7

申请日：2004-06-14

申请人： STABLE SOLUTIONS, INC. ,  Nicoli, David F. ,  DRISCOLL, David F. ,  BISTRIAN, Bruce R.

发明人： NICOLI, David, F. ,  DRISCOLL, David, F. ,  BISTRIAN, Bruce, R.

IPC分类号： G01N33/03

CPC分类号： G01N33/03 ,  G01N15/1456 ,  G01N21/532 ,  G01N2015/0092 ,  G01N2015/1493 ,  G01N2203/0025 ,  Y10T436/2525