公开(公告)号：EP1428813A1

公开(公告)日：2004-06-16

申请号：EP04006759.7

申请日：2000-09-06

申请人： SUMIKA FINE CHEMICALS Co., Ltd.

发明人： Ikemoto, Tetsuya,c/o Sumika Fine Chemicals Co., Lt ,  Gao, Wei-Guo,c/o Sumika Fine Chemicals Co., Ltd. ,  Arai, Nobuhiro,c/o Sumika Fine Chemicals Co., Ltd. ,  Igi, Masami,c/o Sumika Fine Chemicals Co., Ltd.

IPC分类号： C07C33/46 ,  C07C29/40 ,  C07C51/265 ,  C07C65/34 ,  C07D307/87

CPC分类号： C07D307/87 ,  C07C29/40 ,  C07C33/46 ,  C07C51/265 ,  C07C51/373 ,  C07C65/34

摘要： Citalopram can be industrially and economically produced and at a high yield by reacting a compound of the following formula [VI] with 3-(dimethylamino)propyl chloride in the presence of at least one of N,N,N',N'-tetramethylethylenediamine and 1,3-dimethyl-2-imidazolidinone and a condensing agent. The compound of the following formula [III], which is a key compound for the production of citalopram, can be easily produced by subjecting the compound of the following formula [II] to reduction and cyclization.

摘要翻译： 西酞普兰可以在工业和经济上生产，并通过使下式ⅥVI的化合物与3-（二甲基氨基）丙基氯在N，N，N'，N'-四甲基乙二胺和1 ，3-二甲基-2-咪唑啉酮和缩合剂。 通过使下列化学式ÄIIÜ的化合物还原和环化，可以容易地制备下列式ÄIIIÜ的化合物，它是生产西酞普兰的关键化合物。