公开(公告)号：EP0092909B1

公开(公告)日：1987-08-19

申请号：EP83301683.5

申请日：1983-03-25

申请人： SUMITOMO CHEMICAL COMPANY, LIMITED

发明人： Kotera, Norio ,  Tada, Kazuhiro ,  Masaki, Shinzaburo ,  Goto, Kunihisa ,  Kaneoya, Tatsuo

IPC分类号： C07C147/12 ,  B01J27/20 ,  B01J25/02 ,  B01J23/74

CPC分类号： C07C323/00 ,  C07C317/00

公开(公告)号：EP0092909A2

公开(公告)日：1983-11-02

申请号：EP83301683.5

申请日：1983-03-25

申请人： SUMITOMO CHEMICAL COMPANY, LIMITED

发明人： Kotera, Norio ,  Tada, Kazuhiro ,  Masaki, Shinzaburo ,  Goto, Kunihisa ,  Kaneoya, Tatsuo

IPC分类号： C07C147/12 ,  B01J27/20 ,  B01J25/02 ,  B01J23/74

CPC分类号： C07C323/00 ,  C07C317/00

摘要： A process for producing aminophenyl-β-hydroxyethylsulfone of the formula (I),
which comprises steps:

(1) condensing nitrohalobenzene with mercaptoethanol in the presence of an alkali hydroxide and at least one reaction medium selected from N-alkyl-substituted amides and sulfoxides to produce mono-nitrophenyl-β-hydroxyethylsulfide of the formula (II):

(2) oxidizing the mononitrophenyl-β-hydroxyethylsulfide (II) to produce mononitrophenyl-β-hydroxyethylsulfone of the formula (III):
and (3) reducing the mononitrophenyl-β-hydroxyethylsulfone to produce the aminophenyl-β-hydroxyethylsulfone of the formula (I). This compound is useful as an intermediate for aminophenyl-β-sulfatoethylsulfone represented by the following formula:
which is an important intermeidate for vinyl sulfone type reactive dyes largely used for dyeing cellulose fiber materials.

公开(公告)号：EP0007738B1

公开(公告)日：1982-12-29

申请号：EP79301351.7

申请日：1979-07-10

申请人： SUMITOMO CHEMICAL COMPANY, LIMITED

发明人： Fujii, Yozo ,  Yamaguchi, Hiromichi ,  Tada, Kazuhiro ,  Kaneoya, Tatsuo ,  Takata, Takeshi ,  Kotera, Norio

IPC分类号： C07C102/00 ,  C07C103/44 ,  C07C93/14

CPC分类号： C07C233/16

公开(公告)号：EP0092909A3

公开(公告)日：1985-04-17

申请号：EP83301683

申请日：1983-03-25

申请人： SUMITOMO CHEMICAL COMPANY, LIMITED

发明人： Kotera, Norio ,  Tada, Kazuhiro ,  Masaki, Shinzaburo ,  Goto, Kunihisa ,  Kaneoya, Tatsuo

IPC分类号： C07C147/12 ,  B01J27/20 ,  B01J25/02 ,  B01J23/74

CPC分类号： C07C323/00 ,  C07C317/00

摘要： A process for producing aminophenyl-β-hydroxyethylsulfone of the formula (I),
which comprises steps:
(1) condensing nitrohalobenzene with mercaptoethanol in the presence of an alkali hydroxide and at least one reaction medium selected from N-alkyl-substituted amides and sulfoxides to produce mono-nitrophenyl-β-hydroxyethylsulfide of the formula (II):
(2) oxidizing the mononitrophenyl-β-hydroxyethylsulfide (II) to produce mononitrophenyl-β-hydroxyethylsulfone of the formula (III):
and (3) reducing the mononitrophenyl-β-hydroxyethylsulfone to produce the aminophenyl-β-hydroxyethylsulfone of the formula (I). This compound is useful as an intermediate for aminophenyl-β-sulfatoethylsulfone represented by the following formula:
which is an important intermeidate for vinyl sulfone type reactive dyes largely used for dyeing cellulose fiber materials.

公开(公告)号：EP0007738A1

公开(公告)日：1980-02-06

申请号：EP79301351.7

申请日：1979-07-10

申请人： SUMITOMO CHEMICAL COMPANY, LIMITED

发明人： Fujii, Yozo ,  Yamaguchi, Hiromichi ,  Tada, Kazuhiro ,  Kaneoya, Tatsuo ,  Takata, Takeshi ,  Kotera, Norio

IPC分类号： C07C102/00 ,  C07C103/44 ,  C07C93/14

CPC分类号： C07C233/16

摘要： An N-substituted amide of a lower aliphatic acid, preferably N,N-dimethylformamide, or a solvent mixture including such an amide, is used as the solvent for the reaction of a 2,4-diaminophenyl ether with an acylating agent to produce the corresponding 2-amino- 4-acylaminophenyl ether. Such a solvent or solvent mixture may also be employed as the reduction solvent for the catalytic reduction of a 2,4-dinitrophenyl ether to the corresponding 2,4-diaminophenyl ether. The hydrogenation reaction product mixture can be employed directly in the above-mentioned acylation reaction, without concentration or separation of the 2,4-diaminophenyl ether. The reduction and acylation processes according to the invention give a better selectivity and yield of the required products than the corresponding conventional processes using other solvents.

摘要翻译： 使用低级脂族酸，优选N，N-二甲基甲酰胺或包含这种酰胺的溶剂混合物的N-取代酰胺作为2,4-二氨基苯基醚与酰化剂反应的溶剂， 相应的2-氨基-4-酰基氨基苯基醚。 也可以使用这种溶剂或溶剂混合物作为用于将2,4-二硝基苯醚催化还原成相应的2,4-二氨基苯基醚的还原溶剂。 氢化反应产物混合物可以直接用于上述酰化反应中，而不会浓缩或分离2,4-二氨基苯基醚。 根据本发明的还原和酰化方法比使用其它溶剂的相应常规方法提供了所需产物的更好的选择性和产率。