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    Beta-lactam compounds and their production
    1.
    发明公开
    Beta-lactam compounds and their production 失效
    Beta-Lactamverbindungen und deren Herstellung。

    公开(公告)号：EP0229384A2

    公开(公告)日：1987-07-22

    申请号：EP86117997.6

    申请日：1986-12-23

    申请人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED

    发明人： Sunagawa, Makoto Sumitomo Pharmaceuticals Co.,Ltd. ,  Nozaki, Yoshihito Sumitomo Pharmaceuticals Co.,Ltd ,  Sasaki, Akira Sumitomo Pharmaceuticals Co.,Ltd. ,  Matsumura, Haruki Sumitomo Pharmaceuticals Co.,Ltd

    IPC分类号： C07C229/30 ,  C07C323/00 ,  C07D205/08 ,  C07D307/52 ,  C07D405/06

    CPC分类号： C07D405/06 ,  C07D205/08 ,  C07D307/52 ,  C07D309/30 ,  Y02P20/55

    摘要： Described are amino acid compounds of the formula:

    wherein R is a lower alkyl group, R, is a hydrogen atom or a protecting group for carboxyl, R 2 is a hydrogen atom, a protecting group for amino, an optionally substituted allyl group of the formula:
    (wherein R 3 and R 4 are each a hydrogen atom, a lower alkyl group or an aryl group), a beta-hydroxyethyl group in which the hydroxyl group is optionally protected, a formylmethyl group in which the formyl group is optionally protected, a carboxymethyl group in which the carboxyl group is protected or a 2-furylmethyl group and X is an optionally protected carboxyl group, a hydroxymethyl group in which the hydroxyl group is optionally protected or a substituted mercaptomethyl group of the formula: -CH 2 SR 5 (wherein R s is an aryl group or an ar(lower)alkyl group), which are useful intermediates in the synthesis of 1-alkylcarbapenem compounds.

    摘要翻译： 描述了下式的氨基酸化合物：其中R是低级烷基，R 1是氢原子或羧基保护基，R 2是氢原子，氨基保护基，任选取代的烯丙基 式（CH 3）（式中，R 3和R 4各自为氢原子，低级烷基或芳基），羟基可以被保护的β-羟乙基，甲酰基为甲酰基的甲酰基 任选保护的羧基被保护的羧甲基或2-呋喃基甲基，X是任选保护的羧基，羟基被任选保护的羟甲基或下式的取代巯基乙基：-CH 2 S R 5 （其中R5是芳基或芳（低级）烷基），它们是合成1-烷基碳青霉烯化合物的有用中间体。