公开(公告)号：EP1873187A1

公开(公告)日：2008-01-02

申请号：EP06731680.2

申请日：2006-04-12

申请人： SUMITOMO SEIKA CHEMICALS CO., LTD.

发明人： KOBAYASHI, Shinji c/o SUMITOMO SEIKA CHEMICALS CO., LTD.. ,  TERAMOTO, Masaki c/o SUMITOMO SEIKA CHEMICALS CO., LTD. ,  KATOU, Makoto c/o SUMITOMO SEIKA CHEMICALS CO., LTD. ,  IDO, Tohru c/o SUMITOMO SEIKA CHEMICALS CO., LTD.

IPC分类号： C08G65/30

CPC分类号： C08G65/30

摘要： The present invention relates to a method of removing a residual ethylene oxide monomer in polyethylene oxide used as a raw material for pharmaceutical preparations. More particularly, the method of the present invention comprises retaining high-molecular weight polyethylene oxide particles at a temperature not higher than a crystal melting point of the polyethylene oxide in the absence of an aggregation inhibitor under an atmospheric pressure in the standing state and, then, cooling the particles to 40 °C or lower under an atmospheric pressure and in the standing state, thereby, reducing a residual ethylene oxide monomer concentration to 1 ppm or lower without influencing on physical properties such as a specific surface area of the high-molecular weight polyethylene oxide particles.

摘要翻译： 本发明涉及一种去除用作药物制剂原料的聚环氧乙烷中残留的环氧乙烷单体的方法。 更具体地说，本发明的方法包括在常压下在不存在聚集抑制剂的情况下，在不高于聚环氧乙烷的结晶熔点的温度下保持高分子量聚环氧乙烷粒子，然后， ，在大气压下和在常压状态下将颗粒冷却至40℃或更低，从而将残留环氧乙烷单体浓度降低至1ppm或更低，而不影响物理性能如高分子量比表面积 重量的聚环氧乙烷颗粒。

公开(公告)号：EP1873187B1

公开(公告)日：2012-05-16

申请号：EP06731680.2

申请日：2006-04-12

申请人： SUMITOMO SEIKA CHEMICALS CO., LTD.

发明人： KOBAYASHI, Shinji c/o SUMITOMO SEIKA CHEMICALS CO., LTD.. ,  TERAMOTO, Masaki c/o SUMITOMO SEIKA CHEMICALS CO., LTD. ,  KATOU, Makoto c/o SUMITOMO SEIKA CHEMICALS CO., LTD. ,  IDO, Tohru c/o SUMITOMO SEIKA CHEMICALS CO., LTD.

IPC分类号： C08G65/30

CPC分类号： C08G65/30

摘要： A method of removing residual ethylene oxide monomer from polyethylene oxide to be used as a raw material for medicinal preparations. The method is characterized by allowing particles of high-molecular polyethylene oxide to stand in a stationary state at a temperature not higher than the melting point of crystals of the polyethylene oxide at atmospheric pressure in the absence of an aggregation inhibitor and then cooling the particles in a stationary state to 40°C or lower at atmospheric pressure to thereby reduce the residual ethylene oxide monomer concentration to 1 ppm or lower without influencing physical properties of the high-molecular polyethylene oxide particles, such as specific surface area.

摘要翻译： 一种从聚环氧乙烷中除去残留的环氧乙烷单体以用作药物制剂的原料的方法。 该方法的特征在于，在不存在聚集抑制剂的情况下，使高分子量聚环氧乙烷颗粒在不高于聚环氧乙烷晶体熔点的温度下静置，然后将颗粒冷却至 在大气压下静置至40℃或更低，由此将残余环氧乙烷单体浓度降低至1ppm或更低，而不影响高分子量聚环氧乙烷颗粒的物理性能，如比表面积。