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    CLOCK GENE EXPRESSION LEVEL MODIFIER
    1.
    发明公开
    CLOCK GENE EXPRESSION LEVEL MODIFIER 审中-公开
    MODIFIZIERER DES CLOCK-GENGENEXPRESSIONSNIVEAUS

    公开(公告)号：EP3042653A4

    公开(公告)日：2017-05-31

    申请号：EP14840209

    申请日：2014-08-26

    申请人： SUNTORY HOLDINGS LTD

    发明人： KASAJIMA NAOKI ,  KOMINAMI MASARU

    IPC分类号： A61K31/351 ,  A23L33/10 ,  A23L33/105 ,  A61K31/7048 ,  A61K36/00 ,  A61K36/18 ,  A61K36/63 ,  A61P25/20 ,  A61P43/00

    CPC分类号： A61K31/7048 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/351 ,  A61K36/63 ,  A61K2236/00

    摘要： Provided is a clock gene expression level regulator which has a long history of being eaten and is high in safety, easily obtainable and superior in processability. Specifically provided is a clock gene expression level regulator comprising, as an active component, at least one compound selected from the group consisting of oleuropein, 3,4-DHPEA-EA, derivatives thereof, and salts of the foregoing. The clock gene expression level regulator of the present invention can regulate the expression levels of the Per1 and Bmall genes in antiphase to each other, thereby entraining the expression rhythms of the Per and Bmal genes to their normal phases.

    摘要翻译： 本发明提供了一种时钟基因表达水平调节剂，其具有长期被食用并且安全性高，易于获得且加工性优异。 具体提供了一种时钟基因表达量调节剂，其包含选自橄榄苦苷，3,4-DHPEA-EA，其衍生物和前述的盐的至少一种化合物作为活性组分。 本发明的时钟基因表达水平调节剂可以调节彼此反相的Per1和Bmall基因的表达水平，由此将Per和Bmal基因的表达节律带到它们的正常阶段。