公开(公告)号：EP3268465A1

公开(公告)日：2018-01-17

申请号：EP16764215.6

申请日：2016-03-11

申请人： Syz Cell Therapy Co.

发明人： ZHOU, Xiangjun ,  LI, Jin ,  HAN, Yanyan ,  WU, Dongyun ,  LIU, Junyun ,  TAO, Ran ,  TANG, Longqing

IPC分类号： C12N5/0783 ,  C12N5/0784 ,  C12N5/0786 ,  A61K38/17 ,  A61P35/00

CPC分类号： A61K39/0011 ,  A61K35/14 ,  A61K35/17 ,  A61K45/06 ,  A61K2039/5154 ,  A61K2039/5158 ,  C12N5/0636 ,  C12N5/0639 ,  C12N2501/998 ,  C12N2502/1114 ,  C12N2502/1121

摘要： Provided is a method of treating a cancer in an individual using activated T cells or PBMCs induced by antigen presenting cells (such as dendritic cells) loaded with a plurality of tumor antigen peptides. The method may further comprise administration of the antigen presenting cells loaded with the plurality of tumor antigen peptides to the individual. The methods may be used singly or in combination with an immune checkpoint inhibitor. Also provided are precision therapy methods customized for the individual using neoantigen peptides or based on the mutation load in the tumor of the individual, methods of preparing the activated T cells, methods of monitoring the treatment, methods of cloning tumor-specific T cell receptors, an isolated population of cells comprising the activated T cells, and compositions and kits useful for cancer immunotherapy.

公开(公告)号：EP4219690A3

公开(公告)日：2023-08-30

申请号：EP23156772.8

申请日：2016-03-11

申请人： SYZ Cell Therapy Co.

发明人： ZHOU, Xiangjun ,  LI, Jin ,  HAN, Yanyan ,  WU, Dongyun ,  LIU, Junyun ,  TAO, Ran ,  TANG, Longqing

IPC分类号： C12N5/0783 ,  C12N5/0784 ,  C12N5/0786 ,  A61K38/17 ,  A61P35/00

摘要： Provided is a method of treating a cancer in an individual using activated T cells or PBMCs induced by antigen presenting cells (such as dendritic cells) loaded with a plurality of tumor antigen peptides. The method may further comprise administration of the antigen presenting cells loaded with the plurality of tumor antigen peptides to the individual. The methods may be used singly or in combination with an immune checkpoint inhibitor. Also provided are precision therapy methods customized for the individual using neoantigen peptides or based on the mutation load in the tumor of the individual, methods of preparing the activated T cells, methods of monitoring the treatment, methods of cloning tumor-specific T cell receptors, an isolated population of cells comprising the activated T cells, and compositions and kits useful for cancer immunotherapy.

公开(公告)号：EP4219690A2

公开(公告)日：2023-08-02

申请号：EP23156772.8

申请日：2016-03-11

申请人： SYZ Cell Therapy Co.

发明人： ZHOU, Xiangjun ,  LI, Jin ,  HAN, Yanyan ,  WU, Dongyun ,  LIU, Junyun ,  TAO, Ran ,  TANG, Longqing

IPC分类号： C12N5/0783 ,  C12N5/0784 ,  C12N5/0786 ,  A61K38/17 ,  A61P35/00

摘要： Provided is a method of treating a cancer in an individual using activated T cells or PBMCs induced by antigen presenting cells (such as dendritic cells) loaded with a plurality of tumor antigen peptides. The method may further comprise administration of the antigen presenting cells loaded with the plurality of tumor antigen peptides to the individual. The methods may be used singly or in combination with an immune checkpoint inhibitor. Also provided are precision therapy methods customized for the individual using neoantigen peptides or based on the mutation load in the tumor of the individual, methods of preparing the activated T cells, methods of monitoring the treatment, methods of cloning tumor-specific T cell receptors, an isolated population of cells comprising the activated T cells, and compositions and kits useful for cancer immunotherapy.

公开(公告)号：EP3775166A1

公开(公告)日：2021-02-17

申请号：EP19777370.8

申请日：2019-03-29

申请人： SYZ Cell Therapy Co. ,  HRYZ (Shenzhen) Biotech Co.

发明人： ZHOU, Xiangjun ,  MA, Yifan ,  HAN, Yanyan ,  LI, Jin ,  TANG, Longqing ,  LIU, Junyun ,  WU, Dongyun

IPC分类号： C12N5/0783 ,  C12N5/0784 ,  A61K35/17 ,  A61K38/17 ,  A61P35/00