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公开(公告)号：EP3035940B1
公开(公告)日：2018-10-17
申请号：EP14837132.1
申请日：2014-08-22
发明人： MARTINEZ BOTELLA, Gabriel , HARRISON, Boyd, L. , ROBICHAUD, Albert, Jean , SALITURO, Francesco, Gerald , HERR, Robert, Jason , KARGBO, Robert, Borbo
CPC分类号： C07J43/003 , A61K31/58 , A61K45/06 , C07J1/0059 , C07J7/002 , C07J7/007 , C07J7/0085 , C07J13/007 , C07J21/00 , C07J21/008 , A61K2300/00
摘要： Described herein are neuroactive steroids of the Formula (I): or a pharmaceutically acceptable salt thereof; wherein -------, R1, R2, R5, A and L are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.
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公开(公告)号：EP3488852B1
公开(公告)日：2020-10-28
申请号：EP18199381.7
申请日：2014-08-22
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公开(公告)号：EP3488852A1
公开(公告)日：2019-05-29
申请号：EP18199381.7
申请日：2014-08-22
发明人： MARTINEZ BOTELLA, Gabriel , HARRISON, Boyd, L. , ROBICHAUD, Albert, Jean , SALITURO, Francesco, Gerald , HERR, Robert, Jason , KARGBO, Robert, Borbo
摘要： Described herein are neuroactive steroids of the Formula ( I ):
or a pharmaceutically acceptable salt thereof; wherein ------ , R 1 , R 2 , R 5 , A and L are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.
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