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公开(公告)号：EP3268042A1
公开(公告)日：2018-01-17
申请号：EP16765521.6
申请日：2016-03-11
IPC分类号： A61K39/395 , A61K38/17 , C07K14/705 , C07K16/00
CPC分类号： C07K14/7151 , A61K38/00 , A61K38/1793 , A61K2039/505 , A61K2039/545 , C07K14/525 , C07K16/241 , C07K2317/21 , C07K2319/30 , C07K2319/70
摘要： The invention provides a composition comprising an anti-tumor necrosis factor (TNF)-alpha polypeptide, wherein the composition produces a reduced level of immunogenicity when administered to a subject, as well as a treatment method involving the administration of the composition.
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公开(公告)号：EP2403866B1
公开(公告)日：2018-05-02
申请号：EP10707193.8
申请日：2010-03-04
申请人： Biogen MA Inc.
发明人： GRONKE, Robert S. , ZAANONI, Hector
IPC分类号： C07K1/16
CPC分类号： C07K1/22 , B01D15/26 , B01D15/3804 , B01D15/3828 , B01D2015/3838 , C07K1/165
摘要： The present invention pertains to improved methods of using dye-ligand affinity chromatography for the isolation of antibodies or proteins comprising an antibody fragment (such as Fc fusion proteins) from a mixture of undesirable contaminants. In particular, the use of an organic polymer such as polyethylene glycol (PEG) in the elution phase of an antibody/dye-ligand chromatography isolation procedure results in improved separation of target antibodies from undesirable contaminants. The methods described herein are particularly useful in separating or removing antibody aggregates, misfolded antibodies, and virus contaminants from target antibodies.
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公开(公告)号：EP3183264A1
公开(公告)日：2017-06-28
申请号：EP15763443.7
申请日：2015-08-18
申请人： Biogen MA Inc.
发明人： GRONKE, Robert S. , JAQUEZ, Orlando
IPC分类号： C07K14/555 , C07K14/56 , C07K14/565 , C07K14/435
摘要： The present invention relates to a method for PEGylating interferon beta.
摘要翻译： 本发明涉及PEG化干扰素β的方法。
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4.发明公开USE OF CATION-EXCHANGE CHROMATOGRAPHY IN THE FLOW-THROUGH MODE TO ENRICH POST-TRANSLATIONAL MODIFICATIONS 审中-公开阳离子交换色谱的流方式使用的翻译后修饰的富集
公开(公告)号：EP3102589A1
公开(公告)日：2016-12-14
申请号：EP15710294.8
申请日：2015-02-04
申请人： Biogen MA Inc.
发明人： NG, Austen , GRONKE, Robert S.
IPC分类号： C07K1/18 , C07K14/745 , C07K14/755 , C07K16/00
CPC分类号： C07K1/18 , C07K14/7151 , C07K14/755 , C07K2319/30
摘要： The present invention relates to improved methods in the separation recombinant polypeptides with post-translational modifications from complex mixtures through the use of a cation exchange medium.
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公开(公告)号：EP3782652A1
公开(公告)日：2021-02-24
申请号：EP20180909.2
申请日：2015-08-18
申请人： Biogen MA Inc.
发明人： GRONKE, Robert S. , JAQUEZ, Orlando
IPC分类号： A61K47/60
摘要： The present invention relates to a method for PEGylating interferon beta.
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公开(公告)号：EP3183264B1
公开(公告)日：2020-07-29
申请号：EP15763443.7
申请日：2015-08-18
申请人： Biogen MA Inc.
发明人： GRONKE, Robert S. , JAQUEZ, Orlando
IPC分类号： C07K14/555 , C07K14/56 , C07K14/565 , C07K14/435
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