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    5-SUBSTITUTED INDAZOLE-3-CARBOXAMIDES AND PREPARATION AND USE THEREOF
    3.
    发明公开
    5-SUBSTITUTED INDAZOLE-3-CARBOXAMIDES AND PREPARATION AND USE THEREOF 审中-公开
    5-SUBSTITUIERTE INDAZOL-3-CARBOXAMIDE UND HERSTELLUNG UND VERWENDUNG DAVON

    公开(公告)号：EP3119393A1

    公开(公告)日：2017-01-25

    申请号：EP15765201.7

    申请日：2015-03-20

    申请人： Samumed, LLC

    发明人： HOOD, John ,  KC, Sunil Kumar ,  WALLACE, David Mark ,  MITTAPALLI, Gopi Kumar ,  HOFILENA, Brian Joseph ,  MAK, Chi Ching ,  BOLLU, Venkataiah ,  EASTMAN, Brian

    IPC分类号： A61K31/416

    CPC分类号： C07D231/56 ,  C07B59/002 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D498/08

    摘要： Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease, fibrotic disorders, cartilage (chondral) defects, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, and neurological conditions/disorders/diseases linked to overexpression of DYRK1A.

    摘要翻译： 公开了用于治疗各种疾病和病症的吲唑化合物。 更具体地，本公开涉及吲哚化合物或其类似物在治疗以Wnt途径信号传导（例如癌症，异常细胞增殖，血管发生，阿尔茨海默氏病，肺部疾病，纤维化病症， 软骨（软骨）缺陷和骨关节炎），由Wnt途径信号传导介导的细胞事件的调节以及与DYRK1A的过度表达有关的神经病症/病症/疾病。