公开(公告)号：EP3016954A1

公开(公告)日：2016-05-11

申请号：EP14735966.5

申请日：2014-07-04

申请人： Sandoz AG

发明人： STEFINOVIC, Marijan ,  REECE, Hayley ,  SUNKARA, Asha

IPC分类号： C07D487/04 ,  A61K31/55 ,  A61P35/00

CPC分类号： C07D487/04 ,  A61K9/2009 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/2059

摘要： The present disclosure relates to polymorphic forms of the hydrochloride salt of ponatinib (“compound 1”) and to processes for the preparation of these polymorphic forms. The present disclosure also generally relates to a pharmaceutical composition comprising the forms, as well of methods of using the form(s) in the treatment of disorders associated with pathological cellular proliferation, such as neoplasms, and cancer.

公开(公告)号：EP3016954B1

公开(公告)日：2018-10-31

申请号：EP14735966.5

申请日：2014-07-04

申请人： Sandoz AG

发明人： STEFINOVIC, Marijan ,  REECE, Hayley ,  SUNKARA, Asha

IPC分类号： C07D487/04 ,  A61K31/55 ,  A61P35/00

CPC分类号： C07D487/04 ,  A61K9/2009 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/2059

摘要： The present disclosure relates to polymorphic forms of the hydrochloride salt of ponatinib (“compound 1”) and to processes for the preparation of these polymorphic forms. The present disclosure also generally relates to a pharmaceutical composition comprising the forms, as well of methods of using the form(s) in the treatment of disorders associated with pathological cellular proliferation, such as neoplasms, and cancer.