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公开(公告)号：EP2596011A2
公开(公告)日：2013-05-29
申请号：EP11810427.2
申请日：2011-07-21
发明人： COLLINGWOOD, Trevor , COOPER, Laurence J.,N. , GREGORY, Philip D. , HOLMES, Michael C. , MILLER, Jeffrey C. , REBAR, Edward J. , REIK, Andreas , URNOV, Fyodor
IPC分类号： C07K14/00
CPC分类号： C07K14/70539 , A61K35/17 , C07K2319/81 , C12N15/907 , C12N2800/80
摘要： Disclosed herein are methods and compositions for modulating the expression of a HLA locus or for selectively deleting or manipulating a HLA locus or HLA regulator.
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公开(公告)号：EP2596011B1
公开(公告)日：2018-10-03
申请号：EP11810427.2
申请日：2011-07-21
发明人： COLLINGWOOD, Trevor , COOPER, Laurence J.,N. , GREGORY, Philip D. , HOLMES, Michael C. , MILLER, Jeffrey C. , REBAR, Edward J. , REIK, Andreas , URNOV, Fyodor
IPC分类号： C07K14/00
CPC分类号： C07K14/70539 , A61K35/17 , C07K2319/81 , C12N15/907 , C12N2800/80
摘要： Disclosed herein are methods and compositions for modulating the expression of a HLA locus or for selectively deleting or manipulating a HLA locus or HLA regulator.
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公开(公告)号：EP1720995B1
公开(公告)日：2015-05-06
申请号：EP05756438.7
申请日：2005-02-03
发明人： MILLER, Jeffrey C. , ZHANG, Lei
IPC分类号： C07K14/715 , C07K14/435 , C12N9/14 , C12N15/85 , C12N9/22 , C12N15/62 , C07K14/47
CPC分类号： A61K35/12 , C07K14/43595 , C07K14/4717 , C07K14/715 , C07K2319/00 , C07K2319/09 , C07K2319/81 , C12N9/14 , C12N9/22 , C12N15/62 , C12N15/85 , C12N2800/80
摘要： Disclosed herein are methods and compositions for targeted cleavage of a genomic sequence, targeted alteration of a genomic sequence, and targeted recombination between a genomic region and an exogenous polynucleotide homologous to the genomic region. The compositions include fusion proteins comprising a cleavage domain (or cleavage half-domain) and an engineered zinc finger domain, as well as polynucleotides encoding same. Fusion proteins comprising cleavage half-domains are used in pairs, to reconstitute a functional cleavage domain. In these fusion proteins, the zinc finger domain can be N-terminal to the cleavage half-domain, or the cleavage half-domain can be N-terminal to the zinc finger domain. The availability of fusion endonucleases having these different polarities allows targeting (and thereby binding) of zinc finger endonucleases either to opposite strands of the DNA target or to the same strand of the DNA target, thereby increasing the number of possible sequences which can be targeted and cleaved by the fusion proteins.
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公开(公告)号：EP2534173A1
公开(公告)日：2012-12-19
申请号：EP11740153.9
申请日：2011-02-07
发明人： DOYON, Yannick , MILLER, Jeffrey C.
IPC分类号： C07K14/195
CPC分类号： C12N15/907 , C07K7/06 , C07K14/47 , C07K2319/50 , C07K2319/80 , C07K2319/81 , C12N9/22 , C12N15/85 , C12Y301/21004
摘要： Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and fusion proteins; and cells comprising said polynucleotides and/or fusion proteins. Also described are methods of using these polypeptides and polynucleotides, for example for targeted cleavage of a genomic sequence.
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5.发明公开ENGINEERED ZINC FINGER PROTEINS TARGETING PLANT GENES INVOLVED IN FATTY ACID BIOSYNTHESIS 有权操纵锌指蛋白FOR ABZIELUNG在脂肪酸生物合成基因植物是否涉及
公开(公告)号：EP2491127A1
公开(公告)日：2012-08-29
申请号：EP10825333.7
申请日：2010-10-22
CPC分类号： C12N15/8218 , C07K14/415 , C12N9/22 , C12N15/8216 , C12N15/8247 , C12Y203/01041 , C12Y301/00
摘要： The present dislosure relates to engineered zinc finger proteins that target genes in plants involved in fatty acid biosynthesis. Methods of using such zinc finger proteins in modulating gene expression, gene inactivation, and targeted gene modification are also provided.
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公开(公告)号：EP2408921A2
公开(公告)日：2012-01-25
申请号：EP10753815.9
申请日：2010-03-18
IPC分类号： C12N15/66
CPC分类号： A61K35/17 , A61K48/00 , C07K14/70596 , C07K14/7158 , C07K2319/81
摘要： Disclosed herein are methods and compositions for modulating activity of
CXCR4 genes, for example using zinc finger transcription factors (ZF-TFs) or zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding ZF-TFs or ZFNs, vectors comprising polynucleotides encoding ZF-TFs or ZFNs and cells comprising polynucleotides encoding ZF-TFs or ZFNs and/or cells comprising ZF-TF or ZFNs are also provided.-
公开(公告)号：EP3152319A1
公开(公告)日：2017-04-12
申请号：EP15803156.7
申请日：2015-06-05
发明人： DOYON, Yannick , MILLER, Jeffrey C.
CPC分类号： C12N15/01 , C07K2319/00 , C07K2319/80 , C12N9/22 , C12N15/102 , C12N15/63 , C12Y301/00
摘要： Methods and compositions for genetic alteration of cells are provided.
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8.发明公开FAD3 PERFORMANCE LOCI AND CORRESPONDING TARGET SITE SPECIFIC BINDING PROTEINS CAPABLE OF INDUCING TARGETED BREAKS 审中-公开FAD3-PERFORMANCE位点与任务目标设定具体的结合蛋白诱导靶BREAKS
公开(公告)号：EP2893006A1
公开(公告)日：2015-07-15
申请号：EP13834682.0
申请日：2013-09-05
发明人： COGAN, Noel , FORSTER, John , HAYDEN, Matthew , SAWBRIDGE, Tim , SPANGENBERG, German , WEBB, Steven R. , GUPTA, Manju , AINLEY, William Michael , HENRY, Matthew J. , MILLER, Jeffrey C. , GUSCHIN, Dmitry Y.
IPC分类号： C12N5/10
CPC分类号： C12N15/79 , C12N9/22 , C12N15/63 , C12N15/8241 , C12N15/8247
摘要： A method of gene editing or gene stacking within a FAD3 loci by cleaving, in a site directed manner, a location in a FAD3 gene in a cell, to generate a break in the FAD3 gene and then ligating into the break a nucleic acid molecule associated with one or more traits of interest is disclosed.
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9.发明公开FAD2 PERFORMANCE LOCI AND CORRESPONDING TARGET SITE SPECIFIC BINDING PROTEINS CAPABLE OF INDUCING TARGETED BREAKS 审中-公开FAD2演出场所和相关的目标定特异性结合蛋白，以确保靶向BREAKS
公开(公告)号：EP2892321A2
公开(公告)日：2015-07-15
申请号：EP13834776.0
申请日：2013-09-05
发明人： AINLEY, William Michael , WEBB, Steven R. , SAMUEL, Pon , GUSCHIN, Dmitry Y. , MILLER, Jeffrey C. , ZHANG, Lei
CPC分类号： C12N15/8216 , C07K14/4702 , C07K2319/81 , C12N9/22 , C12N15/102 , C12N15/66 , C12N15/822 , C12N15/8247 , C12N15/902 , C12Y301/00
摘要： Methods and compositions for gene disruption, gene editing or gene stacking within a FAD2 loci by cleaving, in a site directed manner, a location in a FAD2 gene in a soybean cell, to generate a break in the FAD2 gene and then optionally integrating into the break a nucleic acid molecule of interest is disclosed.
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公开(公告)号：EP2027262B1
公开(公告)日：2010-03-31
申请号：EP07795299.2
申请日：2007-05-23
发明人： MILLER, Jeffrey C.
CPC分类号： C12N9/22
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