公开(公告)号：EP2315781A2

公开(公告)日：2011-05-04

申请号：EP09784478.1

申请日：2009-07-07

申请人： Sanofi-Aventis

发明人： BAURIN, Nicolas ,  BERNE, Pierre-François ,  BLANCHE, Francis ,  BONO, Françoise ,  CAMERON, Béatrice ,  DABDOUBI, Tarik ,  HERBERT, Corentin ,  MIKOL, Vincent ,  REMY, Elisabeth

IPC分类号： C07K16/28 ,  C12N15/13 ,  C12N5/18 ,  A61K39/395 ,  A61P35/00

CPC分类号： C07K16/2863 ,  A61K2039/505 ,  C07K16/303 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30

摘要： The present invention relates to FGF-R4 receptor-specific antagonist molecules enabling the inhibition of the activity of said receptor. Said antagonists are, particularly, FGF-R4-specific antibodies enabling the inhibition of the activity of said receptor. The present invention also relates to the therapeutic use of said antibodies, particularly in the field of angiogenesis and in the treatment of certain types of cancer.