公开(公告)号：EP1773835A2

公开(公告)日：2007-04-18

申请号：EP05788772.1

申请日：2005-07-13

申请人： Sanofi-Aventis

发明人： BOURRIE, Bernard ,  CASELLAS, Pierre ,  JEGHAM, Samir ,  PERREAUT, Pierre

IPC分类号： C07D471/04 ,  A61K31/519

CPC分类号： C07D471/04

摘要： The invention concerns pyrido[2,3-d]pyrimidine derivatives, their preparation and their therapeutic application, of general formula (I), in the form of a base or an addition salt to a pharmaceutically acceptable acid, in the form of hydrates or solvates, as well as in the form of enantiomers, diastereoisomers and mixtures thereof. The invention also concerns a method for preparing said derivatives, pharmaceutical compositions containing a compound of general formula (I), and their therapeutic use.

公开(公告)号：EP1902054B1

公开(公告)日：2009-02-18

申请号：EP06778710.1

申请日：2006-06-29

申请人： Sanofi-Aventis

发明人： CASELLAS, Pierre ,  BOURRIE, Bernard ,  PERREAUT, Pierre ,  MUNEAUX, Claude ,  JEGHAM, Samir

IPC分类号： C07D471/04 ,  A61K31/519 ,  A61P35/00

CPC分类号： C07D471/04

摘要： The invention relates to derivatives of pyrido[2,3-d]pyrimidine, to the preparation thereof, and to the therapeutic application of the same. Said compounds are potentially useful for treating cellular proliferation disorders.

公开(公告)号：EP1902054A1

公开(公告)日：2008-03-26

申请号：EP06778710.1

申请日：2006-06-29

申请人： Sanofi-Aventis

发明人： CASELLAS, Pierre ,  BOURRIE, Bernard ,  PERREAUT, Pierre ,  MUNEAUX, Claude ,  JEGHAM, Samir

IPC分类号： C07D471/04 ,  A61K31/519 ,  A61P35/00

CPC分类号： C07D471/04

摘要： The invention relates to derivatives of pyrido[2,3-d]pyrimidine, to the preparation thereof, and to the therapeutic application of the same. Said compounds are potentially useful for treating cellular proliferation disorders.

公开(公告)号：EP1979352A2

公开(公告)日：2008-10-15

申请号：EP07717935.6

申请日：2007-01-12

申请人： Sanofi-Aventis

发明人： PERREAUT, Pierre ,  JEGHAM, Samir ,  BOURRIE, Bernard ,  CASELLAS, Pierre ,  LABROSSE, Jean-Robert ,  DURAND, Florence

IPC分类号： C07D471/04 ,  A61K31/505

CPC分类号： C07D471/04

摘要： The invention relates to pyrido[2,3-d]pyrimidone derivatives, to the preparation thereof and to the therapeutic use thereof, wherein said derivatives are of general formula (I) which follows: (I), in the form of a base or of an addition salt with an acid which is pharmaceutically acceptable, in the form of hydrates or of solvates, and also in the form of enantiomers, diastereoisomers and a mixture thereof. The invention also relates to the process for preparing said derivatives, to pharmaceutical compositions containing a compound of general formula (I), and to the therapeutic use of said compositions.

公开(公告)号：EP1373233B1

公开(公告)日：2007-09-05

申请号：EP02724383.1

申请日：2002-03-27

申请人： Sanofi-Aventis

发明人： FERRARI, Bernard ,  GOUGAT, Jean ,  MUNEAUX, Yvette ,  PERREAUT, Pierre ,  SARRAN, Lionel

IPC分类号： C07D295/18 ,  C07D211/34 ,  C07C237/30 ,  C07C311/19 ,  C07D317/60 ,  C07D319/18 ,  C07D213/40 ,  C07D215/36 ,  C07D205/04 ,  C07D317/66 ,  C07D405/12 ,  C07D271/12 ,  C07D333/62 ,  C07D307/52 ,  C07D307/54 ,  C07D277/80 ,  C07D233/54 ,  C07D213/76 ,  C07D409/12 ,  C07D333/24 ,  C07D317/46

CPC分类号： C07D213/40 ,  C07C311/19 ,  C07D205/04 ,  C07D211/34 ,  C07D213/76 ,  C07D215/36 ,  C07D233/64 ,  C07D271/12 ,  C07D277/80 ,  C07D295/155 ,  C07D295/185 ,  C07D307/52 ,  C07D307/54 ,  C07D307/79 ,  C07D307/81 ,  C07D317/46 ,  C07D317/60 ,  C07D317/66 ,  C07D319/18 ,  C07D333/24 ,  C07D333/62 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D495/04

摘要： The invention relates to compounds having formula (I). Said compounds have an affinity for bradykinin receptors with a selectivity for B1 receptors and they can be used to prepare medicaments that are intended to treat or prevent persistent or chronic inflammatory diseases and inflammation pathologies.