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1.发明授权ANTHRANILSÄUREAMIDE MIT HETEROARYLSULFONYL-SEITENKETTE UND IHRE VERWENDUNG ALS ANTIARRHYTHMISCHE WIRKSTOFFE 有权邻氨基WITH的杂侧链和它们作为抗心律失常活性
公开(公告)号：EP1399423B1
公开(公告)日：2007-11-14
申请号：EP02745333.1
申请日：2002-05-31
IPC分类号： C07D215/36 , A61K31/33 , A61P9/06 , C07D401/12 , C07D333/34 , C07D405/12 , C07D261/10 , C07D271/12 , C07D213/71
CPC分类号： C07D261/10 , A61K31/47 , A61K45/06 , C07D215/36 , C07D217/02 , C07D271/12 , C07D333/34 , C07D401/12 , C07D405/12 , A61K2300/00
摘要： The invention relates to compounds of formula (I), wherein R(1) -R(7) have the meanings cited in the claims. Said compounds act upon the Kv1.5-potassium channel and inhibit a potassium flow in the atrium of the human heart, designated as an ultra-rapidly activating delayed rectifier. As a result, they are particularly suitable for use as novel antiarrhythmic active substances, especially in the treatment and prophylaxis of atrial arrhythmia, e.g. atrial fibrillation (AF) or atrial flutter.
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2.发明授权ANTHRANILSÄUREAMIDE MIT HETEROARYLSULFONYL-SEITENKETTE UND IHRE VERWENDUNG ALS ANTIARRHYTHMISCHE WIRKSTOFFE 有权邻氨基WITH的杂侧链和它们作为抗心律失常活性
公开(公告)号：EP1399423B9
公开(公告)日：2008-02-27
申请号：EP02745333.1
申请日：2002-05-31
IPC分类号： C07D215/36 , A61K31/33 , A61P9/06 , C07D401/12 , C07D333/34 , C07D405/12 , C07D261/10 , C07D271/12 , C07D213/71
CPC分类号： C07D261/10 , A61K31/47 , A61K45/06 , C07D215/36 , C07D217/02 , C07D271/12 , C07D333/34 , C07D401/12 , C07D405/12 , A61K2300/00
摘要： The invention relates to compounds of formula (I), wherein R(1) -R(7) have the meanings cited in the claims. Said compounds act upon the Kv1.5-potassium channel and inhibit a potassium flow in the atrium of the human heart, designated as an ultra-rapidly activating delayed rectifier. As a result, they are particularly suitable for use as novel antiarrhythmic active substances, especially in the treatment and prophylaxis of atrial arrhythmia, e.g. atrial fibrillation (AF) or atrial flutter.
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3.发明公开SUBSTITUIERTE N-ARYLHETEROZYKLEN, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ARZNEIMITTEL 审中-公开取代的N- ARYLHETEROZYKLEN，其制造方法相同，它们作为药物
公开(公告)号：EP1597228A2
公开(公告)日：2005-11-23
申请号：EP04710808.9
申请日：2004-02-13
发明人： SCHWINK, Lothar , STENGELIN, Siegfried , GOSSEL, Matthias , BÖHME, Thomas , HESSLER, Gerhard , STAHL, Petra , GRETZKE, Dirk
IPC分类号： C07D207/14 , C07D207/26 , C07D401/12 , C07D417/12 , C07D401/04 , C07D211/58 , C07D205/04 , C07D405/12 , C07D207/16 , C07D413/12 , C07D403/12 , C07D409/12 , C07D207/34 , C07D405/14 , C07D401/14
CPC分类号： C07D207/26 , C07D205/04 , C07D207/14 , C07D207/16 , C07D207/34 , C07D211/58 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The invention relates to N-arylheterocycles and the physiologically-acceptable salts and physiologically-functional derivatives thereof. Compounds of formula (I), where the groups have the given meanings, the N-oxides and the physiologically-acceptable salts and methods for production thereof are disclosed. The compounds are suitable as anorectics for example.
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