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公开(公告)号：EP4289446A2
公开(公告)日：2023-12-13
申请号：EP23202597.3
申请日：2009-05-28
IPC分类号： A61K47/18
摘要： The present invention relates to a method for increasing aqueous solubility and improving stability of tafluprost in an aqueous ophthalmic solution, comprising the steps of preparing an aqueous ophthalmic solution containing 0.0010-0.0025% tafluprost, 0.075% polysorbate 80, 0.005-0.2% stabilizing agent and substantially no preservatives, and packaging the preservative-free ophthalmic solution in a container consisting essentially of polyethylene.
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公开(公告)号：EP4035656A1
公开(公告)日：2022-08-03
申请号：EP21217057.5
申请日：2009-05-28
IPC分类号： A61K9/08 , A61K31/5575 , A61K47/10 , A61K47/26 , A61K47/18
摘要： The present invention relates to the use of tafluprost for the manufacture of an ophthalmic aqueous solution for the treatment of ocular hypertension and glaucoma, wherein said ophthalmic solution comprises 0.0010-0.0025% w/v tafluprost, 0.075% w/v polysorbate 80, 0.005-0.2% w/v stabilizing agent, and substantially no preservatives in a single dose or unit dose container consisting essentially of polyethylene.
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公开(公告)号：EP4289446A3
公开(公告)日：2024-01-10
申请号：EP23202597.3
申请日：2009-05-28
IPC分类号： A61K9/08 , A61K31/5575 , A61K47/10 , A61K47/26 , A61K47/18
摘要： The present invention relates to a method for increasing aqueous solubility and improving stability of tafluprost in an aqueous ophthalmic solution, comprising the steps of preparing an aqueous ophthalmic solution containing 0.0010-0.0025% tafluprost, 0.075% polysorbate 80, 0.005-0.2% stabilizing agent and substantially no preservatives, and packaging the preservative-free ophthalmic solution in a container consisting essentially of polyethylene.
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公开(公告)号：EP3714877A1
公开(公告)日：2020-09-30
申请号：EP20164602.3
申请日：2009-05-28
IPC分类号： A61K9/08 , A61K47/10 , A61K47/26 , A61K47/18 , A61K31/5575
摘要： The present invention relates to a preservative-free ophthalmic aqueous composition containing prostaglandin (PG hereafter) F2α analogues for treating ocular hypertension and glaucoma.
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5.发明公开
公开(公告)号：EP2127638A1
公开(公告)日：2009-12-02
申请号：EP08397513.6
申请日：2008-05-30
IPC分类号： A61K9/08 , A61K47/10 , A61K47/26 , A61K47/18 , A61K31/5575
CPC分类号： A61K9/0048 , A61K9/08 , A61K31/5575 , A61K47/02 , A61K47/10 , A61K47/183 , A61K47/26 , Y02A50/465
摘要： The present invention relates to an ophthalmic aqueous composition containing PGF2α analogues for treating ocular hypertension and glaucoma, to a method for treating ocular hypertension and glaucoma by administering said composition to a subject in need of such treatment, and to a method for increasing aqueous solubility and stability of PGF2α analogues in an aqueous composition.
摘要翻译： 本发明涉及一种在眼科wässrige组合物含PGF2±类似物用于治疗高眼压和青光眼，一种用于通过施用所述组合物至需要寻求治疗的受试者中治疗高眼压和青光眼，以及用于增加wässrige溶解度的方法 和PGF2±在wässrige组合物类似物的稳定性。
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