-
1.发明公开
公开(公告)号：EP1549292A2
公开(公告)日：2005-07-06
申请号：EP03788929.2
申请日：2003-09-30
IPC分类号： A61K9/107
CPC分类号： A61K9/1075
摘要： The invention relates to pharmaceutical preparations comprising at least one emulsifier, at least one emulsifier adjunct and/or solvent and at least one lipid, characterised in that the mass ratio of emulsifier to emulsifier adjunct and/or solvent (Smix) is 1:1 to 9:1 and the total lipid fraction is > 0 % (m/m). Said preparation at least partly inhibits at least one intestinal enzyme and/or at least one intestinal efflux system. Said preparations may be used to increase the bioavailability of medicaments which are lipophilic and/or substrates for intestinal metabolising enzymes and/or intestinal efflux systems, in particular steroids.
-
2.发明公开17ALPHA-ALKYL-17BETA-OXY-ESTRATRIENE UND ZWISCHENPRODUKTE ZU DEREN HERSTELLUNG, VERWENDUNG DER 17ALPHA-ALKYL-17BETA-OXY-ESTRATRIENE ZUR HERSTELLUNG VON ARZNEIMITTELN SOWIE PHARMAZEUTISCHE PRÄPARATE 有权17α-乙烯烷基17β-OXY-三烯和生产中间产品，17α-乙烯烷基17β-OXY-三烯的药物和药物制剂的生产中使用
公开(公告)号：EP1448591A1
公开(公告)日：2004-08-25
申请号：EP02795080.7
申请日：2002-11-27
发明人： BOHLMANN, Rolf , HEINRICH, Nikolaus , JAUTELAT, Rolf , KROLL, Jorg , PETROV, Orlin , REICHEL, Andreas , HOFFMANN, Jens , LICHTNER, Rosemarie
IPC分类号： C07J41/00 , C07J43/00 , A61K31/567 , A61P5/32
CPC分类号： C07J43/003 , C07J41/0072
摘要： The invention relates to 17α-alkyl-17β-oxy-estra-1,3,5(10)-trienes having an anti-oestrogen action, of general formula (I). The invention also relates to 17-oxo-estra-1,3,5(10)-trienes and 17β-hydroxy-estra-1,3,5(10)-trienes as intermediates for producing the inventive estratrienes. The invention further relates to the use of 17α-alkyl-17β-oxy-estratrienes for the production of medicaments and pharmaceutical preparations containing at least one 17α-alkyl-17β-oxy-estratriene and at least one pharmaceutically acceptable carrier.
-
公开(公告)号：EP1622894A1
公开(公告)日：2006-02-08
申请号：EP04728552.3
申请日：2004-04-21
发明人： CLEVE, Arwed , SCHULZE, Volker , ZOPF, Dieter , HOFFMANN, Jens , REICHEL, Andreas , PARCZYK, Karsten
IPC分类号： C07D403/06 , A61P35/00 , A61K31/4164
CPC分类号： C07D233/86 , A61K31/4178 , C07D403/06
摘要： The invention relates to substituted antiadrogenic pyrrolidines N-[φ-[3-[4-cyan-3-(trifluoromethyl)-phenyl]-5.5-dimethyl-4-oxo2-thioxoimidazoline-1-yle]alkyl] of formula (I) having a salient antiproliferative effect profile. Said invention also relates to a method for producing compounds of the formula (I), pharmaceutical preparations and to the use thereof for producing drugs.
-
-
搜索结果
3 条记录 (耗时 0.011 秒)
