专利检索 ap:("Schering Corporation") AND inv:"LEONG, William W." 第 1 页

1.

发明公开
PROCESS FOR PREPARING CCR-5 RECEPTOR ANTAGONISTS UTILIZING 4-SUBSTITUTED 1-CYCLOPROPANE-SULFONYL-PIPERIDINYL COMPOUNDS 审中-公开
标题翻译：用于生产CCR-5受体拮抗剂使用4-取代的1- CYCLOPROPANSULFONYLPIPERIDINYLVERBINDUNGEN

公开(公告)号：EP2125733A1

公开(公告)日：2009-12-02

申请号：EP07863166.0

申请日：2007-12-20

申请人： Schering Corporation

发明人： TRAVERSE, John F. , KUO, Shen-Chun , LIANG, Feng , LEONG, William W.

IPC分类号： C07D211/98 , C07D401/14

CPC分类号： C07D401/14 , C07D211/96 , C07D401/10 , C07D403/10

摘要： The present invention discloses a novel process to prepare 4-substituted 1-Cyclopropane-sulfonyl-Piperidinyl compounds, which are useful intermediates for the preparation of antagonists of CCR5 receptor and therefore useful for the treatment of HIV virus infected mammals. It specifically discloses a novel process to synthesize 4-[4-[(R)-[1-[cyclopropylsulfonyl)-4-piperidinyl](3-fluorophenyl)methyl]-3(S)-methyl-1-piperazinyl]-1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]-4-methylpiperidine] compounds.