公开(公告)号：EP2834329B1

公开(公告)日：2018-10-17

申请号：EP13771756.7

申请日：2013-03-15

申请人： Schindler, William

发明人： VANDEGRIFF, Kim D. ,  MALAVALLI, Ashok ,  MKRTCHYAN, Gnel

IPC分类号： C07D207/416 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07K14/765 ,  C07K14/805 ,  A61K38/42

CPC分类号： C07K14/805 ,  A61K38/42 ,  C07D207/416 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07K14/765

摘要： The present invention relates to succinimide-activated nitroxyl compounds and methods for the synthesis of such compounds. The present invention also relates to the use of succinimide-activated nitroxyl compounds to prepare nitroxylated proteins, for example nitroxylated heme proteins (e.g., nitroxylated hemoglobin and nitroxylated myoglobin). The nitroxylated proteins are optionally also conjugated to a polyalkylene oxide (PAO), for example to a polyethylene glycol (PEG). Polynitroxylated heme proteins are useful as oxygen therapeutic agents (OTAs). The invention further relates to pharmaceutical compositions of the nitroxylated proteins and methods for the use of nitroxylated proteins in the treatment of various conditions.