公开(公告)号：EP2519538A1

公开(公告)日：2012-11-07

申请号：EP10799265.3

申请日：2010-12-30

申请人： Scynexis, Inc.

发明人： OGBU, Cyprian, Okwara ,  RICHARDSON, Thomas, Edward

IPC分类号： C07K7/64 ,  A61P31/12

CPC分类号： C07K7/645 ,  A61K38/00

摘要： The invention relates to the use of cyclic compounds of general formula (I): wherein A, B, R
1 and R
2 are as defined in the specification, and their use as pharmaceuticals, e.g. in the treatment of HCV infections. In particular, • R
1 is selected from hydrogen, alkyl, alkenyl, XR
3 ; • R
2 is selected from alkyl, alenyl, alkynyl, cycloalkyl, all of which can be optionally substituted; • R
3 is selected from the same moieties of R
2 , plus alkoxycarbonyl. The preferred compounds are cyclosporine analogues carrying an ether functionality on the side chain of Leu-4.