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公开(公告)号：EP1289549B1
公开(公告)日：2008-12-10
申请号：EP01944823.2
申请日：2001-06-15
CPC分类号： C07K14/415 , A61K39/39 , A61K2039/54 , A61K2039/55566 , A61K2039/55588 , C07K2319/00
摘要： The present invention relates to the use of oil bodies as a vaccine adjuvant and delivery system for administration of vaccines by parenteral, mucosal (oral, nasal, pulmonary) and transdermal routes. In addition, the present invention relates to methods of eliciting an immune response in an animal by administering oil body-antigen complexes to said mammal. Finally, the present invention relates to methods of preparing oil body-antigen complexes.
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公开(公告)号：EP0977873A1
公开(公告)日：2000-02-09
申请号：EP98916746.5
申请日：1998-04-23
IPC分类号： C12N15/62 , C12N15/15 , C07K14/815 , C07K14/61 , C12N9/50 , C12N15/57 , A61K38/58 , A61K38/27 , A23L1/305
CPC分类号： C12N15/62 , A23L33/17 , C07K14/61 , C07K14/815 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C07K2319/50 , C07K2319/75 , C12N9/50
摘要： An improved method for recovering recombinantly produced polypeptides is described. The method involves expressing the recombinant polypeptide as a fusion protein with a pro-peptide. The pro-peptide-polypeptide fusion protein can be cleaved and the recombinant polypeptide released under the appropriate conditions.
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公开(公告)号：EP0977873B1
公开(公告)日：2006-10-04
申请号：EP98916746.5
申请日：1998-04-23
IPC分类号： C12N15/62 , C12N15/15 , C07K14/815 , C07K14/61 , C12N9/50 , C12N15/57 , A61K38/58 , A61K38/27 , A23L1/305
CPC分类号： C12N15/62 , A23L33/17 , C07K14/61 , C07K14/815 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C07K2319/50 , C07K2319/75 , C12N9/50
摘要： An improved method for recovering recombinantly produced polypeptides is described. The method involves expressing the recombinant polypeptide as a fusion protein with a pro-peptide. The pro-peptide-polypeptide fusion protein can be cleaved and the recombinant polypeptide released under the appropriate conditions.
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公开(公告)号：EP1289549A2
公开(公告)日：2003-03-12
申请号：EP01944823.2
申请日：2001-06-15
IPC分类号： A61K39/39 , A61K39/385 , A61K39/00 , A61P37/04
CPC分类号： C07K14/415 , A61K39/39 , A61K2039/54 , A61K2039/55566 , A61K2039/55588 , C07K2319/00
摘要： The present invention relates to the use of oil bodies as a vaccine adjuvant and delivery system for administration of vaccines by parenteral, mucosal (oral, nasal, pulmonary) and transdermal routes. In addition, the present invention relates to methods of eliciting an immune response in an animal by administering oil body-antigen complexes to said mammal. Finally, the present invention relates to methods of preparing oil body-antigen complexes.
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