公开(公告)号：EP2573559A1

公开(公告)日：2013-03-27

申请号：EP12175764.5

申请日：2008-06-03

申请人： Senomyx, Inc.

发明人： Tachdjian, Catherine ,  Karanewsky, Donald S. ,  Tang, Xiao-qing ,  Li, Xiaodong ,  Zhang, Feng ,  Servant, Guy ,  Chen, Qing ,  Darmohusodo, Vincent ,  Fine, Richard ,  Fotsing, Joseph R. ,  Hammaker, Jeffrey Robert ,  Kang, Xinshan ,  Kimmich, Rachel, D.A. ,  Klebansky, Boris ,  Liu, Haitian ,  Petrovic, Goran ,  Rinnova, Marketa ,  Adamski-Werner, Sara ,  Yamamoto, Jeffrey ,  Zhang, Hong ,  Zlotnik, Albert ,  Zoller, Mark

IPC分类号： G01N33/53 ,  C07D487/04 ,  C07D215/42 ,  C07D215/54 ,  C07D215/56 ,  C07D239/70 ,  C07D239/94 ,  C07D239/95 ,  C07D417/12 ,  C07D471/04 ,  C07D493/04 ,  C07D495/04 ,  C07D495/14 ,  C07D513/20

CPC分类号： C07D513/04 ,  A23L2/39 ,  A23L2/60 ,  A23L27/30 ,  A23L27/31 ,  A23L27/33 ,  A23L27/34 ,  A23L27/88 ,  C07D215/42 ,  C07D215/54 ,  C07D215/56 ,  C07D239/70 ,  C07D239/84 ,  C07D239/94 ,  C07D239/95 ,  C07D285/16 ,  C07D417/04 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D491/056 ,  C07D493/04 ,  C07D495/04 ,  C07D495/14 ,  C07D513/20 ,  G01N33/566

摘要： The present invention includes methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors, and modifiers capable of modulating chemosensory receptors and their ligands. The present invention also includes modifiers of chemosensory receptors and their ligands having Formula (I), its subgenus, and specific compounds. Furthermore, the present invention includes ingestible compositions comprising the modifiers of chemosensory receptors and their ligands and methods of using the modifiers of chemosensory receptors and their ligands to enhance the sweet taste of an ingestible composition or treat a condition associated with a chemosensory receptor. In addition, the present invention includes processes for preparing the modifiers of chemosensory receptors and their ligands.

摘要翻译： 本发明包括用于鉴定化学感应受体及其配体的改性剂的方法，例如通过确定测试实体是否适合与化学感应受体的金星蝇捕获结构域内的一个或多个相互作用位点相互作用，以及能够调节化学感应受体 及其配体。 本发明还包括具有式（I），其亚属和特定化合物的化学感应受体及其配体的改性剂。 此外，本发明包括含有化学感应受体的调节剂及其配体的可摄入组合物，以及使用化学感应受体及其配体的改性剂以增强可摄取组合物的甜味或治疗与化学感觉受体相关的病症的方法。 此外，本发明包括制备化学感应受体及其配体改性剂的方法。

公开(公告)号：EP2568287A3

公开(公告)日：2013-07-17

申请号：EP12175761.1

申请日：2008-06-03

申请人： Senomyx, Inc.

发明人： Tachdjian, Catherine ,  Karanewsky, Donald S. ,  Tang, Xiao-qing ,  Li, Xiaodong ,  Zhang, Feng ,  Servant, Guy ,  Chen, Qing ,  Darmohusodo, Vincent ,  Fine, Richard ,  Fotsing, Joseph R. ,  Hammaker, Jeffrey Robert ,  Kang, Xinshan ,  Kimmich, Rachel, D.A. ,  Klebansky, Boris ,  Liu, Haitian ,  Petrovic, Goran ,  Rinnova, Marketa ,  Adamski-Werner, Sara ,  Yamamoto, Jeffrey ,  Zhang, Hong ,  Zlotnik, Albert ,  Zoller, Mark

IPC分类号： G01N33/53 ,  C07D487/04 ,  G06F19/16

CPC分类号： C07D513/04 ,  A23L2/39 ,  A23L2/60 ,  A23L27/30 ,  A23L27/31 ,  A23L27/33 ,  A23L27/34 ,  A23L27/88 ,  C07D215/42 ,  C07D215/54 ,  C07D215/56 ,  C07D239/70 ,  C07D239/84 ,  C07D239/94 ,  C07D239/95 ,  C07D285/16 ,  C07D417/04 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D491/056 ,  C07D493/04 ,  C07D495/04 ,  C07D495/14 ,  C07D513/20 ,  G01N33/566

摘要： The present invention includes methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors, and modifiers capable of modulating chemosensory receptors and their ligands. The present invention also includes modifiers of chemosensory receptors and their ligands having Formula (I), its subgenus, and specific compounds. Furthermore, the present invention includes ingestible compositions comprising the modifiers of chemosensory receptors and their ligands and methods of using the modifiers of chemosensory receptors and their ligands to enhance the sweet taste of an ingestible composition or treat a condition associated with a chemosensory receptor. In addition, the present invention includes processes for preparing the modifiers of chemosensory receptors and their ligands.

公开(公告)号：EP2573559B1

公开(公告)日：2019-03-13

申请号：EP12175764.5

申请日：2008-06-03

申请人： Senomyx, Inc.

发明人： Tachdjian, Catherine ,  Karanewsky, Donald S. ,  Tang, Xiao-qing ,  Li, Xiaodong ,  Zhang, Feng ,  Servant, Guy ,  Chen, Qing ,  Darmohusodo, Vincent ,  Fine, Richard ,  Fotsing, Joseph R. ,  Hammaker, Jeffrey Robert ,  Kang, Xinshan ,  Kimmich, Rachel, D.A. ,  Klebansky, Boris ,  Liu, Haitian ,  Petrovic, Goran ,  Rinnova, Marketa ,  Adamski-Werner, Sara ,  Yamamoto, Jeffrey ,  Zhang, Hong ,  Zlotnik, Albert ,  Zoller, Mark

IPC分类号： C07D487/04 ,  C07D215/42 ,  C07D215/54 ,  C07D215/56 ,  C07D239/70 ,  C07D239/94 ,  C07D239/95 ,  C07D417/12 ,  C07D471/04 ,  C07D493/04 ,  C07D495/04 ,  C07D495/14 ,  C07D513/20 ,  G01N33/566 ,  A23L27/30

公开(公告)号：EP2568287A2

公开(公告)日：2013-03-13

申请号：EP12175761.1

申请日：2008-06-03

申请人： Senomyx, Inc.

发明人： Tachdjian, Catherine ,  Karanewsky, Donald S. ,  Tang, Xiao-qing ,  Li, Xiaodong ,  Zhang, Feng ,  Servant, Guy ,  Chen, Qing ,  Darmohusodo, Vincent ,  Fine, Richard ,  Fotsing, Joseph R. ,  Hammaker, Jeffrey Robert ,  Kang, Xinshan ,  Kimmich, Rachel, D.A. ,  Klebansky, Boris ,  Liu, Haitian ,  Petrovic, Goran ,  Rinnova, Marketa ,  Adamski-Werner, Sara ,  Yamamoto, Jeffrey ,  Zhang, Hong ,  Zlotnik, Albert ,  Zoller, Mark

IPC分类号： G01N33/53 ,  C07D487/04

CPC分类号： C07D513/04 ,  A23L2/39 ,  A23L2/60 ,  A23L27/30 ,  A23L27/31 ,  A23L27/33 ,  A23L27/34 ,  A23L27/88 ,  C07D215/42 ,  C07D215/54 ,  C07D215/56 ,  C07D239/70 ,  C07D239/84 ,  C07D239/94 ,  C07D239/95 ,  C07D285/16 ,  C07D417/04 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D491/056 ,  C07D493/04 ,  C07D495/04 ,  C07D495/14 ,  C07D513/20 ,  G01N33/566

摘要： The present invention includes methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors, and modifiers capable of modulating chemosensory receptors and their ligands. The present invention also includes modifiers of chemosensory receptors and their ligands having Formula (I), its subgenus, and specific compounds. Furthermore, the present invention includes ingestible compositions comprising the modifiers of chemosensory receptors and their ligands and methods of using the modifiers of chemosensory receptors and their ligands to enhance the sweet taste of an ingestible composition or treat a condition associated with a chemosensory receptor. In addition, the present invention includes processes for preparing the modifiers of chemosensory receptors and their ligands.

摘要翻译： 本发明包括用于鉴定化学感应受体及其配体的修饰物的方法，例如通过确定测试实体是否适合于与化学感应受体的金星蝇domains结构域内的一个或多个相互作用位点相互作用，以及能够调节化学感应受体的修饰物 和它们的配体。 本发明还包括化学感应受体的修饰物及其具有式（I）的配体，其亚属和特定化合物。 此外，本发明包括包含化学感应受体及其配体的调节剂的可摄取组合物以及使用化学感应受体及其配体的调节剂来增强可摄入组合物的甜味或治疗与化学感应受体相关的病症的方法。 另外，本发明包括制备化学感应受体及其配体的修饰物的方法。