公开(公告)号：EP3851127A1

公开(公告)日：2021-07-21

申请号：EP19861156.8

申请日：2019-09-11

申请人： Seoul National University R & DB Foundation

发明人： JEONG, Jae Min ,  KIM, Young Ju ,  LEE, Yun-Sang ,  PARK, Ji Yong

IPC分类号： A61K51/02 ,  A61K51/04

摘要： The present invention relates to a composition for detecting hydrogen sulfide or measuring a concentration of hydrogen sulfide, and a composition comprising same as an effective ingredient for diagnosing or imaging in vivo inflammation, tissues having hypoxic damage, or cancer. The composition for detecting hydrogen sulfide or measuring a concentration of hydrogen sulfide according to the present invention, which comprises the compound represented by formula 1 ( 99m Tc-alpha-hydroxy acid) having alpha-hydroxy acid labeled with 99m Tc, enables the detection or concentration measurement of hydrogen sulfide in in-vitro and in-vivo levels and, as such, can be advantageously used for detecting hydrogen sulfide and measuring a concentration of hydrogen sulfide and furthermore for discovering biological roles of hydrogen sulfide in vivo, especially, for detecting, imaging, and quantitatively measuring hydrogen sulfide in a disease selected from the group consisting of angiogenesis, inflammation, cancer, Alzheimer's disease, cardiovascular ischemia, and cerebrovascular ischemia, or in hypoxic tissues.