公开(公告)号：EP2173170A2

公开(公告)日：2010-04-14

申请号：EP08796893.9

申请日：2008-07-30

申请人： Sepracor Inc.

发明人： HEFFERNAN, Michele, L.R. ,  DORSEY, James, M. ,  FANG, Qun, Kevin ,  FOGLESONG, Robert, J. ,  HOPKINS, Seth, C. ,  OGBU, Cyprian, O. ,  SOUKRI, Mustapha ,  SPEAR, Kerry, L.

IPC分类号： A01N43/16 ,  A61K31/35

CPC分类号： A61K31/407 ,  C07D491/04 ,  C07D495/04

摘要： This invention provides fused heterocycles having the formula: in which R
1 is a member selected from the group consisting of H, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl. R
2 is a member selected from the group consisting of H substituted or unsubstituted alkenyl, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl. R
3 is a member selected from the group consisting of H
1 C
1 -C
6 substituted or unsubstituted alkyl, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl. R
4 is a member selected from OH and O
- X
+ , in which X
+ is positive ion which is a member selected from organic positive ions and inorganic positive ions. Substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl moieties have the formula: in which Ar is a member selected from the group consisting of substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl. The index n is an integer from 1 to 4. Formulae A, B.

公开(公告)号：EP2057162A2

公开(公告)日：2009-05-13

申请号：EP07796659.6

申请日：2007-07-02

申请人： Sepracor Inc.

发明人： DORSEY, James, M. ,  HOPKINS, Seth, C. ,  FOGLESONG, Robert, J. ,  HEFFERNAN, Michele, L.r. ,  JONES, Michael, L. ,  PERALES, Joseph, B. ,  FANG, Qun, Kevin ,  OGBU, Cyprian, O. ,  JONES, Steven, W. ,  SOUKRI, Mustapha ,  VARNEY, Mark, A. ,  SPEAR, Kerry, L.

IPC分类号： C07D487/04 ,  C07D491/04 ,  C07D495/04 ,  C07D513/04 ,  A61K31/381 ,  A61K31/407 ,  A61K31/429 ,  A61K31/4162 ,  A61P25/00

CPC分类号： C07D491/04 ,  C07D495/04

摘要： This invention provides novel inhibitors of the enzyme D-amino acid oxidase as well as pharmaceutical compositions including the compounds of the invention. Also provided are methods for the treatment and prevention of neurological disorders, such as neuropsychiatric and neurodegenerative diseases, as well as pain, ataxia and convulsion. The compounds of the invention have the general structure wherein Q is a member selected from O, S, CR1 and N, X and Y are members independently selected from CR2, O, S, N and NR3.