公开(公告)号：EP2617704A1

公开(公告)日：2013-07-24

申请号：EP13150247.8

申请日：2008-06-02

申请人： Sepracor Inc.

发明人： Shao, Liming ,  Wang, Fengjiang ,  Malcolm, Scott, Christopher ,  Hewitt, Michael, Charles ,  Ma, Jianguo ,  Ribe, Seth ,  Varney, Mark, A. ,  Campbell, Una ,  Engel, Sharon, Rae ,  Hardy, Larry, Wendell ,  Koch, Patrick ,  Schreiber, Rudy ,  Spear, Kerry, L

IPC分类号： C07C215/42 ,  C07C217/52 ,  A61P25/24 ,  A61P25/28

CPC分类号： C07C215/42 ,  A61K31/135 ,  A61P25/24 ,  A61P25/28 ,  C07B2200/07 ,  C07C217/52 ,  C07C217/76 ,  C07C2601/14

摘要： Phenyl-substituted cyclohexylamine derivatives and method for their synthesis and characterization are disclosed. Use of these compounds to treat/prevent neurological disorders as well as methods for their synthesis are set forth herein. Exemplary compounds of the invention inhibit reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine (e.g. from the synaptic cleft) and modulate one or more monoamine transporter. Pharmaceutical formulations incorporating compounds of the invention are also provided.

摘要翻译： 公开了苯基取代的环己胺衍生物及其合成和表征的方法。 本文阐述了这些化合物治疗/预防神经系统疾病及其合成方法的用途。 本发明的示例性化合物抑制内源性单胺如多巴胺，5-羟色胺和去甲肾上腺素的再摄取（例如来自突触裂缝）并调节一种或多种单胺转运蛋白。 还提供了掺入本发明化合物的药物制剂。