公开(公告)号：EP4446325A1

公开(公告)日：2024-10-16

申请号：EP22903595.1

申请日：2022-12-09

申请人： Shandong Luye Pharmaceutical Co., Ltd.

发明人： TIAN, Jingwei ,  YE, Liang ,  LU, Jing ,  ZHANG, Jianzhao ,  LEI, Hui ,  BAI, Xinfa ,  WANG, Wenyan ,  ZHANG, Rui

IPC分类号： C07D487/04 ,  C07D487/14 ,  C07D491/048 ,  C07D495/04 ,  C07D495/14 ,  A61K31/517 ,  A61K31/519 ,  A61P35/00 ,  A61P37/00 ,  A61P25/00 ,  A61P31/12

摘要： The present invention relates to a series of compounds for regulating activity of a protein kinase, in particular a compound for inhibiting activity of PLK1. The present invention further provides a pharmaceutical composition containing the compound, and a use of the compound and the pharmaceutical composition thereof in preparing a drug for preventing or treating diseases caused by and/or related to dysregulation of PLK1 kinase activity.