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1.发明公开
公开(公告)号：EP4342913A1
公开(公告)日：2024-03-27
申请号：EP22804030.9
申请日：2022-05-19
发明人： ZHANG, Xinmin , NIAN, Weihong , XU, Chuanying , HE, Feng , ZHOU, Qing , ZHANG, Jianbing
摘要： The present application discloses a chimeric antigen receptor molecule for specifically recognizing BAFF-R, a nucleic acid encoding the receptor molecule, an engineered immune effector cell comprising the receptor molecule, a pharmaceutical composition, and a use thereof. The receptor molecule comprises a structural domain that specifically recognizes the BAFF-R and an activation stimulation structural domain, and can activate a downstream signal path after specifically recognizing and binding the BAFF-R, thereby causing, promoting or improving an immune response reaction for the BAFF-R, and finally achieving the purpose of treating or preventing diseases caused by B cell BAFF-BAFF-R signal path imbalance.
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公开(公告)号：EP4146283A1
公开(公告)日：2023-03-15
申请号：EP21726806.9
申请日：2021-04-30
发明人： ZHU, Tong , KHASANOV, Alisher B. , LI, Hui , GUO, Maojun , LI, Haihong , XU, Chuanying , HE, Feng , ZHOU, Qing
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公开(公告)号：EP4105238A1
公开(公告)日：2022-12-21
申请号：EP21754619.1
申请日：2021-02-10
发明人： ZHOU, Qing , XU, Chuanying , NIAN, Weihong , HE, Xiangyu , ZHENG, Xintong , ZHANG, Xinmin , HE, Feng , XIAO, Jing
摘要： The present invention relates to a claudin 18.2 (CLDN18.2) antibody and the use thereof in treating cancers, such as gastric cancer, pancreatic cancer, and esophageal cancer.
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公开(公告)号：EP4105237A1
公开(公告)日：2022-12-21
申请号：EP21753717.4
申请日：2021-02-10
发明人： ZHOU, Qing , XU, Chuanying , NIAN, Weihong , HE, Xiangyu , ZHANG, Xinmin , ZHENG, Xintong , HE, Feng , XIAO, Jing
IPC分类号： C07K16/30 , A61K39/395 , A61K39/00 , A61P35/00
摘要： Provided are an antibody against claudin 18.2 (cldn18.2) and a use thereof in diagnosing and treating cancer of the stomach, pancreas and esophagus.
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公开(公告)号：EP4105234A1
公开(公告)日：2022-12-21
申请号：EP21754327.1
申请日：2021-02-10
发明人： HE, Xiangyu , NIAN, Weihong , XU, Chuanying , ZHENG, Xintong , ZHANG, Xinmin , XIAO, Jing , HE, Feng , ZHOU, Qing
IPC分类号： C07K16/28 , C12N15/13 , A61K39/395 , A61P35/00 , G01N33/68
摘要： The present application relates to an anti-CD47 single-domain antibody and a use thereof, and a method for preparing the antibody. The single-domain antibody comprises a CDR selected from the following CDRs: (1) CDR1, CDR2, and CDR3 shown by SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO:3; or (2) CDR1, CDR2, and CDR3 shown by SEQ ID NO: 6, SEQ ID NO: 7, and SEQ ID NO: 8.
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