专利检索 ap:("Shanghai Institute Of Materia Medica Chinese Academy of Sciences") AND inv:"WANG, Qi" 第 1 页

1.

发明公开
FUSED RING PYRIMIDINE AMINO COMPOUND AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND USE THEREOF 审中-公开

公开(公告)号：EP4001267A1

公开(公告)日：2022-05-25

申请号：EP20844824.1

申请日：2020-07-17

申请人： Shanghai Institute Of Materia Medica Chinese Academy of Sciences

发明人： XIONG, Bing , LI, Jia , GENG, Meiyu , SHEN, Jingkang , ZANG, Yi , AI, Jing , CHEN, Danqi , WANG, Qi , DONG, Ying , PENG, Xia , JI, Yinchun , TAN, Qian

IPC分类号： C07D239/84 , A61K31/517 , A61P35/00

摘要： The present disclosure relates to a fused ring pyrimidine amino compound and a preparation method, a pharmaceutical composition, and a use thereof. Specifically disclosed in the present disclosure are the compound shown in formula I, a pharmaceutically acceptable salt thereof, a tautomer thereof, a stereoisomer thereof, a metabolite thereof, a metabolic precursor thereof, or a prodrug thereof. The fused ring pyrimidine amino compound of the present application has good inhibitory activity against DDRs, particularly DDR2, and has a good therapeutic effect on tumors and fibrotic diseases, especially pulmonary inflammation and pulmonary fibrosis. Also disclosed in the present disclosure are a preparation method for the compound shown in formula I, and a use thereof.