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公开(公告)号：EP3862348A1
公开(公告)日：2021-08-11
申请号：EP19867602.5
申请日：2019-09-30
发明人： CHEN, Xiaohua , LI, Jia , CHENG, Yu , ZHOU, Yubo , NIE, Huijun , WANG, Yujie , TIAN, Hongtao , KAN, Weijuan , MI, Tian , HU, Xiaobei , ZHOU, Binshan , YAN, Kenian , XU, Gaoya , ZHONG, Yuhua , FENG, Lei
IPC分类号： C07D401/14 , C07D401/04 , C07D413/14 , C07D491/107 , C07D487/10 , C07D498/10 , C07D419/14 , C07D417/14 , C07D409/14 , C07D405/14 , A61K31/45 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/538 , A61P35/00 , A61P37/00 , A61P25/00 , A61P29/00
摘要： The present invention relates to a polysubstituted isoindoline compound as shown in general formula (I), and a preparation method, a pharmaceutical composition and the use thereof. In particular, the polysubstituted isoindoline compound is provided in the present invention as a class of novel CRL4 CRBN E3 ubiquitin ligase modulators in structure, wherein same has a stronger antitumor activity and antitumor spectrum, and can be used to prepare drugs for treating CRL4 CRBN E3 ligase-related diseases.
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2.发明公开
公开(公告)号：EP3896062A1
公开(公告)日：2021-10-20
申请号：EP19893951.4
申请日：2019-12-06
发明人： CHEN, Xiaohua , LI, Jia , CHENG, Yu , ZHOU, Yubo , NIE, Huijun , WANG, Yujie , GUO, Andi , KAN, Weijuan
IPC分类号： C07D401/04 , C07D401/14 , A61K31/4412 , A61K31/4745 , A61P35/00
摘要： The present invention relates to an isoindoline compound as represented by general formula (I) and used as a CRBN regulator, and a preparation method, a pharmaceutical composition, and an application of the isoindoline compound. Specifically, a class of polysubstituted isoindoline compound provided in the present invention, as a class of CRL4 CRBN E3 ubiquitin ligase regulator having a novel structure, has good anti-tumor activity and immunoregulatory activity, and can be used for preparing drugs for treating diseases associated with a CRL4 CRBN E3 ubiquitin ligase.
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