公开(公告)号：EP3470415A1

公开(公告)日：2019-04-17

申请号：EP17802189.5

申请日：2017-05-24

申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences

发明人： JIANG, Hualiang ,  LIU, Hong ,  GENG, Meiyu ,  ZHENG, Mingyue ,  AI, Jing ,  WANG, Yulan ,  WU, Xiaowei ,  LI, Shuangjie ,  PENG, Xia ,  LI, Chunpu ,  CHEN, Kaixian ,  WANG, Bao

IPC分类号： C07D487/04 ,  A61K31/5025 ,  A61K31/5377 ,  A61K31/541

摘要： The present invention provides a compound comprising a 5-membered heterocycle fused with a pyridazinone, wherein the compound is used as an FGFR kinase inhibitor, and a manufacturing method and application thereof. The invention specifically provides a compound as represented by formula (I). Various radicals are as defined in the specification. The compound provided by the invention effectively inhibits an activity of an FGFR kinase, and can be used to manufacture a pharmaceutical product for treating a disease related to the activity of the FGFR kinase.