公开(公告)号：EP2881395B1

公开(公告)日：2018-09-05

申请号：EP13825341.4

申请日：2013-07-24

申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences ,  Shanghai Acebright Pharmaceuticals Co., Ltd.

发明人： ZHANG, Ao ,  MIAO, Zehong ,  YE, Na ,  HUAN, Xiajuan ,  SONG, Zilan ,  CHEN, Chuanhuizi ,  CHEN, Yi ,  DING, Jian

IPC分类号： C07D487/04 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/502 ,  A61P9/10 ,  A61P25/28 ,  A61P35/00

CPC分类号： C07D487/04 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/502

摘要： Provided is a piperazinotriazole compound represented by general formula I or an isomer, a pharmaceutically acceptable salt, ester, prodrug or hydrate thereof. Also provided are a method for preparing the compound, a drug composition containing the compound, and a use thereof as a high-selectivity poly(ADP-ribose)polymerase-1 (PARP 1) inhibitor in the preparation of drugs for the prevention and / or treatment of PARP-related diseases.

公开(公告)号：EP2881395A1

公开(公告)日：2015-06-10

申请号：EP13825341.4

申请日：2013-07-24

申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences

发明人： ZHANG, Ao ,  MIAO, Zehong ,  YE, Na ,  HUAN, Xiajuan ,  SONG, Zilan ,  CHEN, Chuanhuizi ,  CHEN, Yi ,  DING, Jian

IPC分类号： C07D487/04 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/502 ,  A61P9/10 ,  A61P25/28 ,  A61P35/00

CPC分类号： C07D487/04 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/502

摘要： Provided is a piperazinotriazole compound represented by general formula I or an isomer, a pharmaceutically acceptable salt, ester, prodrug or hydrate thereof. Also provided are a method for preparing the compound, a drug composition containing the compound, and a use thereof as a high-selectivity poly(ADP-ribose)polymerase-1 (PARP 1) inhibitor in the preparation of drugs for the prevention and / or treatment of PARP-related diseases.

摘要翻译： 本发明提供一种由通式表示的异构体，药学上可接受的盐，酯，前药或水合物的I或其化合物piperazinotriazole。 这样提供了用于制备所述化合物，药物组合物含有该化合物，并且作为高选择性的聚（ADP-核糖）在制备药物用于预防聚合酶-1（PARP 1）抑制剂及其使用的方法和/ 或治疗的PARP有关的疾病。