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公开(公告)号：EP1674446B1
公开(公告)日：2011-08-10
申请号：EP03785457.7
申请日：2003-12-19
发明人： ZHANG, Fuli , HU, Meng , ZHAO, Lizhi , GE, Mengya
IPC分类号： C07C211/38 , C07C209/08 , A61P25/28
CPC分类号： C07C209/08 , C07C211/38
摘要： A new method of preparing memantine hydrochloride, comprises the following steps: reacting 1-bromo-3, 5-dimethyl adamantane and urea/formic acid with formic acid also acting as the solvent; hydrolysising with aqueous inorganic acid; alkalifying, extracting and acidifying with hydrochloric acid; finally collecting target compound. The method uses cheaper raw materials and conducts in homogeneous phase under mild conditions. It can reach high yield and good product purity, and be suitable for macrochemistry. The purity of crude product is 99.0%, and reaches 99.98% after first recrystallization, yield: 69.5%, bp: 332ºC (DSC).
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2.发明公开
公开(公告)号：EP1674446A1
公开(公告)日：2006-06-28
申请号：EP03785457.7
申请日：2003-12-19
发明人： ZHANG, Fuli , HU, Meng , ZHAO, Lizhi , GE, Mengya
IPC分类号： C07C211/38 , C07C209/08 , A61P25/28
CPC分类号： C07C209/08 , C07C211/38
摘要： A new method of preparing memantine hydrochloride, comprises the following steps: reacting 1-bromo-3,5-dimethyl adamantane and urea/formic acid with formic acid also acting as the solvent; hydrolysising with aqueous inorganic acid; alkalifying, extracting and acidifying with hydrochloric acid; finally collecting target compound. The method uses cheaper raw materials and conducts in homogeneous phase under mild conditions. It can reach high yield and good product purity, and be suitable for macrochemistry. The purity of crude product is 99.0%, and reaches 99.98% after first recrystallization, yield: 69.5%, mp: 332 C (DSC).
摘要翻译： 一种新的盐酸美金刚的方法，包括以下步骤：使1-溴-3,5-二甲基金刚烷与脲/甲酸与还可作为溶剂的甲酸反应; 用无机酸水溶液水解; 用盐酸碱化，提取和酸化; 最后收集目标化合物。 该方法使用较便宜的原料，并在温和条件下均匀进行。 它可以达到高产量和良好的产品纯度，适用于宏观化学。 粗产物纯度为99.0％，第一次重结晶后达到99.98％，产率为69.5％，mp：332℃（DSC）。
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