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公开(公告)号：EP4029865A1
公开(公告)日：2022-07-20
申请号：EP20862539.2
申请日：2020-09-09
发明人： WANG, Zhe , BAI, Haiyun , LI, Deliang , QIAN, Anran
IPC分类号： C07D471/04 , C07D405/14 , C07D413/14 , C07D519/00 , A61K31/4375 , A61K31/497 , A61K31/4709 , A61K31/4025 , A61P35/00
摘要： The present invention provides a novel tricyclic aromatic heterocyclic compound, a preparation method therefor, a pharmaceutical composition and an application thereof. Specifically, the present invention provides a compound as represented by the following formula I, or optical isomers, hydrates, and solvates thereof, or pharmaceutically-acceptable salts thereof. Definitions of groups are as stated in the description. The compound as represented by formula I can be used for treating diseases related to a PD-1/PD-L 1 signal pathway.
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2.发明公开
公开(公告)号：EP4159736A1
公开(公告)日：2023-04-05
申请号：EP21809085.0
申请日：2021-05-24
发明人： WANG, Zhe , BAI, Haiyun , QIAN, Anran , LI, Deliang
IPC分类号： C07D487/10 , A61K31/4439 , A61P35/00
摘要： Provided in the present invention are a novel tricyclic aromatic heterocyclic compound and a preparation method therefor, a pharmaceutical composition and a use thereof. Specifically, provided in the present invention is a compound as shown in formula I below, or an optical isomer, a hydrate, a solvate thereof, or a pharmaceutically acceptable salt thereof. The definitions of each group are as specified in the description. The compound of formula I can be used for treating diseases related to a PD-1/PD-L1 signaling pathway.
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3.发明公开
公开(公告)号：EP4151634A1
公开(公告)日：2023-03-22
申请号：EP21804286.9
申请日：2021-05-08
发明人： WANG, Zhe , QIAN, Anran , LI, Deliang
IPC分类号： C07D413/14 , C07D471/04 , C07D207/04 , A61K31/33 , A61P35/00 , A61P37/00
摘要： The preparation of an aromatic heterocyclic derivative as an immunomodulator and the use thereof. Specifically, provided is a compound as represented by formula I below, or an optical isomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof, wherein the definition of each group is as described in the description; and the compound of formula I can be used to treat diseases associated with the PD-1/PD-L1 signaling pathway.
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4.发明公开
公开(公告)号：EP4043457A1
公开(公告)日：2022-08-17
申请号：EP20863959.1
申请日：2020-09-09
发明人： WANG, Zhe , BAI, Haiyun , LI, Deliang , QIAN, Anran
IPC分类号： C07D413/14 , C07D405/14 , C07D487/10 , C07D409/14 , A61K31/4439 , A61K31/4545 , A61P35/00 , A61P37/02
摘要： An aromatic heterocyclic compound having a tricyclic structure and a preparation method therefor and application thereof, and in particular, a compound as shown in formula I, or an optical isomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof. The compound shown in formula I may be used to treat diseases associated with a PD-1/PD-L1 signaling pathway.
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