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公开(公告)号：EP4295891A1
公开(公告)日：2023-12-27
申请号：EP22755493.8
申请日：2022-01-24
发明人： LI, Meng , DU, Qiran , LI, Junfei
摘要： The present application relates to the field of pharmaceutical technology, in particular, to a drug-loaded medical device, including a medical device body and at least one drug coating, the drug coating is attached to at least one side of a surface of the medical device body. The main component of the drug coating includes a macrolide drug. The drug coating includes elongated prismatic crystals each with at least three lateral edges, and/or the drug coating includes crystal clusters of the elongated prismatic crystals each with at least three lateral edges. An aspect ratio of each elongated prismatic crystal is in a range from 1: 1 to 40: 1. The drug-loaded medical device can effectively improve the drug transfer to the blood vessel wall and prolong the concentration of drug in tissue.
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公开(公告)号：EP4241822A1
公开(公告)日：2023-09-13
申请号：EP21888488.0
申请日：2021-10-28
发明人： DU, Qiran , LI, Meng , LI, Junfei
IPC分类号： A61M31/00
摘要： A medical delivery device (20) and a drug delivery system are disclosed. The drug delivery system includes the medical delivery device (20), a dispersed substance (40), a liquid dispersion medium (30) and a balloon catheter (10). The medical delivery device (20) includes a first housing member (21), a second housing member (22) and a push mechanism. The first housing member (21) defines a first storage chamber (23), and the second housing member (22) is disposed over the first housing member (21) and defines a second storage chamber (24). In a first operational configuration of the medical delivery device (20), the first storage chamber (23) is not in communication with the second storage chamber (24). In a second operational configuration of the medical delivery device (20), the first storage chamber (23) is in communication with the second storage chamber (24), allowing the liquid dispersion medium (30) in the first storage chamber (23) to enter the second storage chamber (24) to be mixed with the dispersed substance (40) to produce a dispersion system. In a third operational configuration of the medical delivery device (20), the push mechanism drives the first housing member (21) to move relative to the second housing member (22), causing the dispersion system to flow through a delivery port into an external mechanism. This system allows a dispersion system delivery process that is simpler than conventional processes and associated with a reduced risk of the dispersion system being contaminated due to preparation outside the device.
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