公开(公告)号：EP4094779A1

公开(公告)日：2022-11-30

申请号：EP21744595.6

申请日：2021-01-22

申请人： Shanghai Senhui Medicine Co., Ltd. ,  Shanghai Shengdi Pharmaceutical Co., Ltd ,  Shanghai Hengrui Pharmaceutical Co., Ltd. ,  Jiangsu Hengrui Pharmaceuticals Co., Ltd.

发明人： HUANG, Jian ,  ZHU, Lingjian ,  YU, Xiuzhao ,  ZHU, Bo ,  REN, Wenming ,  TANG, Mi ,  SUN, Xing ,  YANG, Yang ,  LIANG, Jindong ,  HU, Qiyue

IPC分类号： A61K47/68 ,  C07D307/20 ,  C07K16/28 ,  A61P35/00

摘要： The present disclosure relates to a drug conjugate of an Eribulin derivative, a preparation method therefor and an application thereof in medicine. Specifically, provided is an antibody-drug conjugate, which contains an Eribulin derivative drug portion. The present disclosure further relates to a method for treating cancer by administering the antibody-drug conjugate provided herein.

公开(公告)号：EP3545974A1

公开(公告)日：2019-10-02

申请号：EP17861068.9

申请日：2017-10-13

申请人： Suzhou Suncadia Biopharmaceuticals Co., Ltd. ,  Jiangsu Hengrui Medicine Co., Ltd. ,  Shanghai Hengrui Pharmaceutical Co., Ltd.

发明人： SUN, Xing ,  CAO, Guoqing ,  TANG, Mi ,  JIANG, Jiahua ,  YANG, Changyong ,  ZHANG, Lianshan

IPC分类号： A61K39/395 ,  A61K47/68 ,  A61K45/00 ,  A61K31/4745 ,  A61K31/537 ,  A61K38/08 ,  A61K38/06 ,  A61P35/00

摘要： Disclosed is the medical use of an anti-c Met antibody-cytotoxic drug conjugate. In particular, disclosed are an anti-c-Met antibody, an antigen-binding fragment of c-Met, a chimeric antibody and humanized antibody comprising the anti-c-Met antibody CDR region, and an antibody-cytotoxic drug conjugate thereof or pharmaceutically acceptable salt or solvate thereof, and the use of a pharmaceutical composition comprising the humanized anti-c-Met antibody and antigen-binding fragment and the antibody-cytotoxic drug conjugate thereof or the pharmaceutically acceptable salt or solvate thereof as an anti-hepatoma drug.