公开(公告)号：EP4393955A1

公开(公告)日：2024-07-03

申请号：EP22860533.3

申请日：2022-08-24

申请人： Shanghai Sinobay Biotechnology Co., Ltd.

发明人： XU, Jianqing ,  ZHANG, Xiaoyan ,  DING, Xiangqing ,  LIAO, Qibin ,  ZHANG, Dan

IPC分类号： C07K16/30 ,  C07K16/46 ,  C07K19/00 ,  C12N15/13 ,  C12N15/64 ,  C12N15/85 ,  C12N15/86 ,  C12N15/863 ,  A61K39/395 ,  A61P35/00

CPC分类号： A61K39/395 ,  A61P35/00 ,  C07K16/00 ,  C07K16/30 ,  C07K16/46 ,  C07K19/00 ,  C12N15/64 ,  C12N15/85 ,  C12N15/863 ,  C12N15/86

摘要： Provided is an antibody capable of specifically binding to CD47 or an antigen binding fragment thereof. Also provided is a recombinant oncolytic virus, which is operably inserted with or comprises a gene coding sequence of an anti-CD47 antibody or a CD47 ligand, wherein the anti-CD47 antibody comprises an Fc mutant having A330L/I332E mutations (ALIE antibody), i.e., the anti-CD47 antibody is αCD47-Fc(ALIE).Also provided are a preparation method for the recombinant oncolytic virus, a use of the recombinant oncolytic virus in preparation of anti-tumor drugs, and a vaccinia virus Tiantan strain capable of efficiently expressing an αCD47-Fc(ALIE) gene.