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公开(公告)号：EP3339452A1
公开(公告)日：2018-06-27
申请号：EP16858964.6
申请日：2016-10-21
发明人： YU, Hongwei , LV, Yong , LI, Yong , CHEN, Jianbo , CHEN, Shaofeng , LI, Weifeng , ZHANG, Hongmei , ZHU, Yongqiang
摘要： The present invention relates to an optimized fermentation process of coenzyme Q10, particularly to a fermentation process of coenzyme Q10 via flow feeding based on cooperative control of changes of online oxygen consumption rate and conductivity. During the fermentation process of coenzyme Q10 production strains, the oxygen consumption rate is controlled between 30-150 mmol/L·h and the conductivity is maintained between 3.0-30.0ms/cm via flow feeding, so as to facilitate strain growth and the start of coenzyme Q10 synthesis and accumulation. The present invention can substantially increase output of coenzyme Q10 and greatly reduce the production cost with simple process control and strong operability, thus being applicable to large-scale industrial production.
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公开(公告)号：EP3339452B1
公开(公告)日：2020-08-19
申请号：EP16858964.6
申请日：2016-10-21
发明人： YU, Hongwei , LV, Yong , LI, Yong , CHEN, Jianbo , CHEN, Shaofeng , LI, Weifeng , ZHANG, Hongmei , ZHU, Yongqiang
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