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    Nitrogen-containing heterocycle derivatives substituted with cyclic group
    5.
    发明公开
    Nitrogen-containing heterocycle derivatives substituted with cyclic group 审中-公开
    用环状基团取代的含氮杂环衍生物

    公开(公告)号：EP2520567A2

    公开(公告)日：2012-11-07

    申请号：EP11192319.9

    申请日：2007-02-21

    申请人： Shionogi & Co., Ltd.

    发明人： Masui, Moriyasu ,  Adachi, Makoto ,  Mikamiyama, Hidenori ,  Matsumura, Akira ,  Tsuno, Naoki

    IPC分类号： C07D209/08

    CPC分类号： C07D209/08 ,  C07D209/34 ,  C07D215/38 ,  C07D235/08 ,  C07D235/26 ,  C07D249/18 ,  C07D263/58 ,  C07D277/68 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D498/04 ,  C07D513/04

    摘要： A compound represented by:

    Wherein Z is N or CR 1 , A 1 is a nitrogen-containing aromatic monocyclic group which is optionally substituted, a nitrogen-containing aromatic fused cyclic group which is optionally substituted etc., A 2 is an aromatic hydrocarbon cyclic group or an aromatic heterocyclic group, each optionally having a substituent, R 1 , R 2 , R a , R b , R c and R d are each independently hydrogen, hydroxy, etc., w is 2 or 3, t is 1 or 2, X is -CONR 5 (CR 3 R 4 )n-, -NR 5 CONR 6 (CR 3 R 4 )n-, -(CR 3 R 4 ) m NR 5 CO- etc., m is an integer of 1 to 4, n is an integer of 0 to 4, R 3 and R 4 are each independently hydrogen, halogen, hydroxy etc., and R 5 and R 6 is hydrogen or lower alkyl, or a pharmaceutically acceptable salt, or solvate thereof.
    The nitrogen-containing heterocyclic derivative represented by the formula (I) specifically binds to a receptor of NR1/NR2B, and is used as a NR2B receptor antagonist.

    摘要翻译： 由下式表示的化合物：其中Z是N或CR1，A1是任选被取代的含氮芳族单环基团，任选被取代的含氮芳族稠合环状基团等，A2是芳族烃环状基团或 芳香族杂环基，各自任选具有取代基，R 1，R 2，R a，R b，R c和R d各自独立地为氢，羟基等，w为2或3，t为1或2，X为-CONR 5（CR 3 R 4） n - ， - NR5CONR6（CR3R4）n - ， - （CR3R4）mNR5CO-等，m为1至4的整数，n为0至4的整数，R3和R4各自独立地为氢，卤素，羟基等 并且R5和R6是氢或低级烷基，或其药学上可接受的盐或溶剂化物。 由式（I）表示的含氮杂环衍生物特异性结合NR 1 / NR 2 B的受体，并用作NR 2 B受体拮抗剂。