公开(公告)号：EP4194459A1

公开(公告)日：2023-06-14

申请号：EP22206730.8

申请日：2017-06-19

申请人： Shionogi & Co., Ltd

发明人： SHIBAHARA, Setsuya ,  FUKUI, Nobuaki ,  MAKI, Toshikatsu ,  ANAN, Kosuke

IPC分类号： C07D498/14 ,  A61P31/16 ,  A61K31/5383

摘要： The present invention provides a process for preparing a compound of the formula (II):

wherein R 2 is unsubstituted alkyl,
characterized by reacting a compound of the formula (I):

wherein R 1 is hydrogen or a protecting group other than unsubstituted alkyl,
with a compound of the formula: R 2 -OH, wherein R 2 is as defined above, in the presence of a sodium salt and/or a magnesium salt.

公开(公告)号：EP3473629A1

公开(公告)日：2019-04-24

申请号：EP17815337.5

申请日：2017-06-19

申请人： Shionogi & Co., Ltd.

发明人： SHIBAHARA, Setsuya ,  FUKUI, Nobuaki ,  MAKI, Toshikatsu ,  ANAN, Kosuke

IPC分类号： C07D498/14 ,  A61K31/5383 ,  C07B61/00

摘要： The present invention provides a process for preparing a compound of the formula (II):

wherein R 2 is unsubstituted alkyl,
characterized by reacting a compound of the formula (I):

wherein R 1 is hydrogen or a protecting group other than unsubstituted alkyl,
with a compound of the formula: R 2 -OH, wherein R 2 is as defined above, in the presence of a sodium salt and/or a magnesium salt.