公开(公告)号：EP1721906A1

公开(公告)日：2006-11-15

申请号：EP05719869.9

申请日：2005-03-03

申请人： Shionogi Co., Ltd.

发明人： Nishitani, Yasuhiro, c/o Shionogi & Co., Ltd. ,  Yasukata, Tatsuro, c/o Shionogi & Co., Ltd. ,  Yamawaki, Kenji, c/o Shionogi & Co., Ltd.

IPC分类号： C07D501/56 ,  A61K31/546 ,  A61P31/04

CPC分类号： C07D501/00

摘要： A compound of Formula 1:

(wherein A is optionally substituted lower alkylene (substituent: mono- or di- lower alkyl, lower alkylidene, or lower alkylene having two or more carbons); Z + is either of the groups shown below:

(wherein R 1 and R 2 are each independently hydrogen, optionally substituted amino lower alkyl or optionally substituted cyclic amino; R 3 is hydrogen or amino; X is N or CR 4 (R 4 is hydrogen or optionally substituted lower alkyl)), a pharmaceutically acceptable salt or a solvate thereof.

摘要翻译： 式1的化合物：其中A为任选取代的低级亚烷基（取代基：具有两个或更多个碳的单或二低级烷基，低级亚烷基或低级亚烷基）; Z +为以下所示的基团之一：（其中R1 和R2各自独立地为氢，任选取代的氨基低级烷基或任选取代的环状氨基; R3为氢或氨基; X为N或CR4（R4为氢或任选取代的低级烷基）），其药学上可接受的盐或溶剂化物。