公开(公告)号：EP1594513B1

公开(公告)日：2011-08-10

申请号：EP04701730.6

申请日：2004-01-13

申请人： Shire LLC

发明人： MICKLE, Travis ,  PICCARIELLO, Thomas ,  MONCRIEF, James, Scott ,  BOERTH, Nancy, Johnston ,  BISHOP, Barney

IPC分类号： A61K45/06 ,  A61K31/485 ,  A61K47/48

CPC分类号： A61K31/70 ,  A61K31/485 ,  A61K45/06 ,  A61K47/549 ,  A61K2300/00

摘要： The invention provides a 'street-safe' version of a controlled substance that permits the therapeutically beneficial effects of the substance while reducing or eliminating the euphoric effects that lead to substance abuse. The invention provides pharmaceutical compositions comprising a controlled substance and a carbohydrate covalently bound to said controlled substance in a manner that renders said controlled substance pharmacologically inactive or substantially diminishes its activity and methods of using the same.