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    ALKYLENE OXIDE DERIVATIVE AND SKIN EXTERNAL PREPARATION CONTAINING THE SAME
    2.
    发明公开
    ALKYLENE OXIDE DERIVATIVE AND SKIN EXTERNAL PREPARATION CONTAINING THE SAME 有权
    阿尔卡尼亚德

    公开(公告)号：EP2174972A1

    公开(公告)日：2010-04-14

    申请号：EP08791636.7

    申请日：2008-07-25

    申请人： Shiseido Company, Ltd. ,  NOF Corporation

    发明人： OHMORI, Takashi ,  ISHIKUBO, Akira ,  SUGIYAMA, Yuki ,  MATSUI, Yuko ,  KAWASOE, Tomoyuki ,  TEZUKA, Yoji ,  MIZUNO, Hiroyasu ,  MARUYAMA, Kei-ichi

    IPC分类号： C08G65/28 ,  A61K8/86 ,  A61K31/77 ,  A61P17/16 ,  A61Q1/02 ,  A61Q19/00

    CPC分类号： A61Q1/02 ,  A61K8/86 ,  A61Q19/00 ,  C08G65/2609 ,  C08G65/2615 ,  C08G65/337 ,  C08L71/02

    摘要： The present invention is to provide a new compound having a rough skin improving effect, excellent in safety, excellent in texture in use, especially free of sticky feeling, excellent in refreshing feeling, and capable to improve the base agent stability as a component.
    An alkylene oxide derivative is characterized by being represented by the below-described general formula (I):

            (formula I) Z-{O-[(AO) a -(EO) b ]-R} 2      (I)

    (In the formula, Z is the residue obtained by removing hydroxyl groups from the dimer diol, EO is an oxyethylene group, AO is an oxyalkylene group having 3 to 4 carbon atoms, and the addition form is block-type. The symbols a and b are the average addition mole numbers of the above-described oxyalkylene group and the oxyethylene group, respectively, and they are 1≦ 2 × a≦ 150 and 1≦ 2 × b≦ 150. The percentage of the oxyethylene groups with respect to the sum of the oxyalkylene groups having 3 to 4 carbon atoms and the oxyethylene groups is 10 to 99 mass%. Rs may be either identical to or different from each other, and they are hydrocarbon groups having 1 to 4 carbon atoms.)

    摘要翻译： 本发明提供一种具有粗糙的皮肤改善效果，安全性优异，使用质地优异，特别是无粘性，清爽感好，能够提高作为成分的基剂稳定性的新化合物。 氧化烯衍生物的特征在于由下述通式（I）表示：ƒ€ƒ€ƒ€ƒ€ƒ€ƒ（式I）Z- {O - [（AO）a - （EO）b] -R} 2€ƒ€ƒ€ƒ（I）（在该式中，Z是通过从二聚二醇除去羟基获得的残基，EO是氧化乙烯基，AO是 具有3〜4个碳原子的氧化烯基，加成形式为嵌段型，符号a和b分别为上述氧化烯基和氧化乙烯基的平均加成摩尔数，为1‰| 2×a‰| 150和1‰| 2×b‰| 150.氧化乙烯基相对于具有3〜4个碳原子的氧化烯和氧化乙烯基的总和的比例为10〜99质量％ 可以彼此相同或不同，它们是具有1至4个碳原子的烃基）