公开(公告)号：EP0583579B1

公开(公告)日：1997-12-03

申请号：EP93110189.3

申请日：1993-06-25

申请人： Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.

发明人： Cerri, Alberto ,  Bernardi, Luigi ,  Bianchi, Giuseppe ,  Florio, Monica ,  Folpini, Elena ,  Melloni, Piero

IPC分类号： C07J41/00 ,  C07J43/00 ,  A61K31/56 ,  A61K31/57 ,  A61K31/58

CPC分类号： C07J41/0016 ,  C07J41/0005 ,  C07J41/0038 ,  C07J41/0088 ,  C07J43/003

公开(公告)号：EP0583579A3

公开(公告)日：1995-03-22

申请号：EP93110189.3

申请日：1993-06-25

申请人： Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.

发明人： Cerri, Alberto ,  Bernardi, Luigi ,  Bianchi, Giuseppe ,  Florio, Monica ,  Folpini, Elena ,  Melloni, Piero

IPC分类号： C07J41/00 ,  C07J43/00 ,  A61K31/56 ,  A61K31/57 ,  A61K31/58

CPC分类号： C07J41/0016 ,  C07J41/0005 ,  C07J41/0038 ,  C07J41/0088 ,  C07J43/003

摘要： 17-Hydroxyiminomethyl-14β-hydroxy-5β-androstane derivatives of general formula I

wherein the symbol , the symbol , R 1 , R 2 , R 3 and Y have the meaning as indicated in the specification as well as their stereoisomers, Z and E isomers, tautomers, optical isomers and mixtures thereof and their pharmaceutically acceptable salts. Processes for their preparation, pharmaceutical compositions and uses for the making of a medicament containing them are also disclosed.

公开(公告)号：EP0583579A2

公开(公告)日：1994-02-23

申请号：EP93110189.3

申请日：1993-06-25

申请人： Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.

发明人： Cerri, Alberto ,  Bernardi, Luigi ,  Bianchi, Giuseppe ,  Florio, Monica ,  Folpini, Elena ,  Melloni, Piero

IPC分类号： C07J41/00 ,  C07J43/00 ,  A61K31/56 ,  A61K31/57 ,  A61K31/58

CPC分类号： C07J41/0016 ,  C07J41/0005 ,  C07J41/0038 ,  C07J41/0088 ,  C07J43/003

摘要： 17-Hydroxyiminomethyl-14β-hydroxy-5β-androstane derivatives of general formula I

wherein the symbol , the symbol , R 1 , R 2 , R 3 and Y have the meaning as indicated in the specification as well as their stereoisomers, Z and E isomers, tautomers, optical isomers and mixtures thereof and their pharmaceutically acceptable salts. Processes for their preparation, pharmaceutical compositions and uses for the making of a medicament containing them are also disclosed.

摘要翻译： 17-肟基14的β-羟基-β-通式5个甾衍生物I worin符号<--->，符号@，R <1>，R <2> [R <3>和Y 具有如在本说明书以及其立体异构体，Z和E异构体，互变异构体，光学异构体及其混合物的药学上可接受的盐和它们中所示的含义。 它们的制备方法，药物组合物和使用含有这些化合物的药物中的决策是如此游离缺失盘。