公开(公告)号：EP2493472B1

公开(公告)日：2016-12-07

申请号：EP10827343.4

申请日：2010-10-22

申请人： Signal Pharmaceuticals, LLC

发明人： HARRIS, Roy, L. ,  SAPIENZA, John ,  SHEVLIN, Graziella ,  PAPA, Patrick ,  LEE, Branden, Gingsee ,  PACKARD, Garrick ,  ZHAO, Jingjing ,  JOKIEL, Patrick, Anthony ,  MORTENSEN, Deborah ,  RIGGS, Jennifer ,  GAMBOA, Juan, Antonio ,  BEAUCHAMPS, Marie, Georges ,  KREILEIN, Matthew, Michael ,  KOTHARE, Mohit, Atul ,  PERRIN-NINKOVIC, Sophie ,  PYE, Philip ,  LEONG, William, Wei-Hwa ,  ELSNER, Jan ,  CHOUDHURY, Anusuya

IPC分类号： A61K31/497

CPC分类号： C07D471/04 ,  C07D241/20 ,  C07D487/04 ,  C07D498/14 ,  C07D519/00

公开(公告)号：EP2493472A1

公开(公告)日：2012-09-05

申请号：EP10827343.4

申请日：2010-10-22

申请人： Signal Pharmaceuticals, LLC

发明人： HARRIS, Roy, L. ,  SAPIENZA, John ,  SHEVLIN, Graziella ,  PAPA, Patrick ,  LEE, Branden, Gingsee ,  PACKARD, Garrick ,  ZHAO, Jingjing ,  JOKIEL, Patrick, Anthony ,  MORTENSEN, Deborah ,  RIGGS, Jennifer ,  GAMBOA, Juan, Antonio ,  BEAUCHAMPS, Marie, Georges ,  KREILEIN, Matthew, Michael ,  KOTHARE, Mohit, Atul ,  PERRIN-NINKOVIC, Sophie ,  PYE, Philip ,  LEONG, William, Wei-Hwa ,  ELSNER, Jan ,  CHOUDHURY, Anusuya

IPC分类号： A61K31/497

CPC分类号： C07D471/04 ,  C07D241/20 ,  C07D487/04 ,  C07D498/14 ,  C07D519/00

摘要： Provided herein are methods to prepare Heteroaryl Compounds having the following structure: Forumula (I) or Formula (II): wherein R
1 -R
4 are as defined herein. The Heteroaryl compounds are useful for treating or preventing cancer, inflammatory conditions, immunological conditions, neurodegenerative diseases, diabetes, obesity, neurological disorders, age-related diseases, or cardiovascular conditions.