公开(公告)号：EP4328223A3

公开(公告)日：2024-11-06

申请号：EP23205984.0

申请日：2012-04-20

申请人： Signal Pharmaceuticals, LLC

发明人： BENNETT, Brydon ,  ELSNER, Jan ,  ERDMAN, Paul ,  HILGRAF, Robert ,  LEBRUN, Laurie Ann ,  MCCARRICK, Meg ,  MOGHADDAM, Mehran ,  NAGY, Mark A. ,  NORRIS, Stephen ,  PAISNER, David A. ,  SLOSS, Marianne ,  ROMANOW, William J. ,  SATOH, Yoshitaka ,  TIKHE, Jayashree ,  YOON, Won Hyung ,  DELGADO, Maria Mercedes

IPC分类号： C07D239/48 ,  C07D405/02 ,  C07D401/12 ,  C07D409/12

摘要： Provided herein is a compound of formula (I)

or a pharmaceutically acceptable salt, tautomer, stereoisomer, enantiomer, isotopologue, or prodrug thereof, wherein R 1 and R 2 are as defined herein. Also provided are methods and reaction intermediates for preparing said compound.

公开(公告)号：EP4328223A2

公开(公告)日：2024-02-28

申请号：EP23205984.0

申请日：2012-04-20

申请人： Signal Pharmaceuticals, LLC

发明人： BENNETT, Brydon ,  ELSNER, Jan ,  ERDMAN, Paul ,  HILGRAF, Robert ,  LEBRUN, Laurie Ann ,  MCCARRICK, Meg ,  MOGHADDAM, Mehran ,  NAGY, Mark A. ,  NORRIS, Stephen ,  PAISNER, David A. ,  SLOSS, Marianne ,  ROMANOW, William J. ,  SATOH, Yoshitaka ,  TIKHE, Jayashree ,  YOON, Won Hyung ,  DELGADO, Maria Mercedes

IPC分类号： C07D409/12

摘要： Provided herein is a compound of formula (I)

or a pharmaceutically acceptable salt, tautomer, stereoisomer, enantiomer, isotopologue, or prodrug thereof, wherein R 1 and R 2 are as defined herein. Also provided are methods and reaction intermediates for preparing said compound.

公开(公告)号：EP3736268A1

公开(公告)日：2020-11-11

申请号：EP20178220.8

申请日：2014-12-19

申请人： Signal Pharmaceuticals, LLC

发明人： CASHION, Daniel Kurt ,  MORTENSEN, Deborah ,  HUANG, Dehua ,  TORRES, Eduardo ,  PARNES, Jason ,  SAPIENZA, John ,  HANSEN, Joshua ,  LEFTHERIS, Katerina ,  CORREA, Matthew ,  DELGADO, Maria Mercedes ,  RAHEJA, Raj ,  PAPA, Patrick ,  BAHMANYAR, Sogole ,  HEGDE, Sayee ,  NORRIS, Stephen Tyson ,  PLANTEVIN-KRENITSKY, Veronique ,  CALABRESE, Andrew Antony ,  CATHERS, Brian Edwin ,  WHITEFIELD, Brandon Wade ,  BENNETT, Brydon

IPC分类号： C07D239/48 ,  C07D403/06 ,  A61K31/506 ,  A61P3/00 ,  A61P11/00 ,  A61P11/06 ,  A61P17/00 ,  A61P19/00 ,  A61P21/00 ,  A61P37/06 ,  C07D405/14 ,  A61K31/505 ,  A61K31/5377 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04

摘要： The invention provides a method for preparing a compound of formula (I):

comprising contacting a compound of formula (Ia)

or a compound of formula (Ic)

with R 1 -L-NH 2 , in an organic solvent, in the presence of a base, under conditions as defined herein. Also provided are reaction intermediates involved in said method as defined herein.