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1.发明公开INHIBITION OF PHOSPHORYLATION OF PRAS40, GSK3-BETA OR P70S6K1 AS A MARKER FOR TOR KINASE INHIBITORY ACTIVITY 有权PRAS40，GSK3 BETA P70S6K1的磷酸化的抑制性标志物TORKINASEHEMMENDE活动
公开(公告)号：EP2909627A2
公开(公告)日：2015-08-26
申请号：EP13824222.7
申请日：2013-10-17
IPC分类号： G01N33/50 , G01N33/574
CPC分类号： G01N33/6842 , A61K31/437 , A61K31/4985 , A61K31/519 , A61K31/522 , C12Q1/485 , G01N33/5011 , G01N2333/9121 , G01N2800/52 , G01N2800/7028
摘要： Provided herein are methods for treating a cancer treatable by inhibition of phosphorylation of PRAS40, GSK3&bgr; or p70S6K1, comprising administering an effective amount of a TOR kinase inhibitor to a patient having a cancer treatable by inhibition of phosphorylation of PRAS40, GSK3&bgr; or p70S6K1.
摘要翻译： 提供在可用于治疗通过抑制PRAS40，GSK3磷酸化的可治疗的癌症的方法？ 或p70S6K1，其包括有效量的TOR激酶抑制剂的给予具有通过抑制PRAS40，GSK3磷酸化的可治疗的癌症的患者？ 或p70S6K1。
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公开(公告)号：EP2908814B1
公开(公告)日：2019-12-25
申请号：EP13824539.4
申请日：2013-10-17
发明人： MORTENSEN, Deborah , RAYMON, Heather , NARLA, Rama, K. , HEGE, Kristen, Mae , FULTZ, Kimberly, Elizabeth , TSUJI, Toshiya
IPC分类号： A61K31/4985 , A61P35/00
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公开(公告)号：EP2908814A2
公开(公告)日：2015-08-26
申请号：EP13824539.4
申请日：2013-10-17
发明人： MORTENSEN, Deborah , RAYMON, Heather , NARLA, Rama, K. , HEGE, Kristen, Mae , FULTZ, Kimberly, Elizabeth , TSUJI, Toshiya
IPC分类号： A61K31/4985 , A61P35/00
CPC分类号： A61K31/4985 , G01N33/5041
摘要： Provided herein are methods for treating or preventing prostate cancer, comprising administering an effective amount of a TOR kinase inhibitor to a patient having prostate cancer.
摘要翻译： 本文提供了用于治疗或预防前列腺癌的方法，其包括向患有前列腺癌的患者施用有效量的TOR激酶抑制剂。
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4.发明授权INHIBITION OF PHOSPHORYLATION OF PRAS40, GSK3-BETA OR P70S6K1 AS A MARKER FOR TOR KINASE INHIBITORY ACTIVITY 有权PRAS40，GSK3-β或P70S6K1作为TOR激酶抑制活性标记物的磷酸化抑制作用
公开(公告)号：EP2909627B1
公开(公告)日：2018-04-04
申请号：EP13824222.7
申请日：2013-10-17
IPC分类号： A61K31/437 , A61K31/4985 , A61K31/519 , A61K31/522 , C12Q1/48 , G01N33/50 , G01N33/68
CPC分类号： G01N33/6842 , A61K31/437 , A61K31/4985 , A61K31/519 , A61K31/522 , C12Q1/485 , G01N33/5011 , G01N2333/9121 , G01N2800/52 , G01N2800/7028
摘要： Provided herein are methods for treating a cancer treatable by inhibition of phosphorylation of PRAS40, GSK3&bgr; or p70S6K1, comprising administering an effective amount of a TOR kinase inhibitor to a patient having a cancer treatable by inhibition of phosphorylation of PRAS40, GSK3&bgr; or p70S6K1.
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5.发明公开METHODS FOR TREATING CANCER USING TOR KINASE INHIBITOR COMBINATION THERAPY 审中-公开VERFAHREN ZUR BEHANDLUNG VON KREBS ANHAND EINER TOR-KINASEHEMMERKOMBINATIONSTHERAPIE
公开(公告)号：EP3131552A1
公开(公告)日：2017-02-22
申请号：EP15780570.6
申请日：2015-04-15
发明人： FULTZ, Kimberly, Elizabeth , TRAN, Tam, Minh , XU, Shuichan , XU, Weiming , TROWE, Torsten , FILVAROFF, Ellen
IPC分类号： A61K31/4985 , C07D487/04
摘要： Provided herein are methods for treating or preventing a cancer, comprising administering an effective amount of a TOR kinase inhibitor and an effective amount a second active agent to a patient having a cancer.
摘要翻译： 本文提供了用于治疗或预防癌症的方法，包括向具有癌症的患者施用有效量的TOR激酶抑制剂和有效量的第二活性剂。
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