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1.发明授权SUBSTITUTED PYRROLOPYRIMIDINE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH 有权取代的吡咯并嘧啶化合物，其组合物及其治疗方法
公开(公告)号：EP2945636B1
公开(公告)日：2017-06-28
申请号：EP14702393.1
申请日：2014-01-15
发明人： CALABRESE, Andrew Antony , JEFFY, Brandon David , ROBINSON, Dale , ZHU, Dan , HUANG, Dehua , ELSNER, Jan , BOYLAN, John Frederick , TEHRANI, Lida , NAGY, Mark, A. , RAHEJA, Raj, Kumar , ERDMAN, Paul , NARLA, Rama, K. , HARRIS, Roy, L. , TRAN, Tam, Minh , RIGGS, Jennifer R. , NING, Yuhong , XU, Shuichan
IPC分类号： A61K31/519 , C07D487/00 , A61P35/00
CPC分类号： A61K31/519 , A61K31/5377 , C07D471/04 , C07D487/04
摘要： The present invention relates to a compound of formula (I): and pharmaceutically acceptable salts, tautomers, stereoisomers, enantiomers, and isotopologues thereof, wherein R 1 , R 2 , R 3 and L are as defined herein. Also provided is a compound or a pharmaceutical composition of the present invention for use in a method for treating or preventing breast cancer.
摘要翻译： 本文提供具有以下结构的吡咯并嘧啶化合物：其中R 1，R 2，R 3和L如本文所定义，包含有效量的吡咯并嘧啶化合物的组合物，以及用于治疗或预防乳腺癌，更特别是三阴性乳腺癌的方法， 包括给有此需要的受试者施用有效量的这种吡咯并嘧啶化合物。
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2.发明公开SUBSTITUTED PYRROLOPYRIMIDINE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH 有权替代品吡咯并嘧啶，ZUSAMMENSETZUNGEN DAVON UND BEHANDLUNGSVERFAHREN DAMIT
公开(公告)号：EP2945636A2
公开(公告)日：2015-11-25
申请号：EP14702393.1
申请日：2014-01-15
发明人： CALABRESE, Andrew Antony , JEFFY, Brandon David , ROBINSON, Dale , ZHU, Dan , HUANG, Dehua , ELSNER, Jan , BOYLAN, John Frederick , TEHRANI, Lida , NAGY, Mark, A. , RAHEJA, Raj, Kumar , ERDMAN, Paul , NARLA, Rama, K. , HARRIS, Roy, L. , TRAN, Tam, Minh , RIGGS, Jennifer R. , NING, Yuhong , XU, Shuichan
IPC分类号： A61K31/519 , C07D487/00 , A61P35/00
CPC分类号： A61K31/519 , A61K31/5377 , C07D471/04 , C07D487/04
摘要： The present invention relates to a compound of formula (I): and pharmaceutically acceptable salts, tautomers, stereoisomers, enantiomers, and isotopologues thereof, wherein R 1 , R 2 , R 3 and L are as defined herein. Also provided is a compound or a pharmaceutical composition of the present invention for use in a method for treating or preventing breast cancer.
摘要翻译： 本文提供具有以下结构的吡咯并嘧啶化合物：其中R1，R2，R3和L如本文所定义，包含有效量的吡咯并嘧啶化合物的组合物，以及用于治疗或预防乳腺癌的方法，更特别是三阴性乳腺癌， 包括向有需要的受试者施用有效量的这种吡咯并嘧啶化合物。
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