公开(公告)号：EP3453762A1

公开(公告)日：2019-03-13

申请号：EP18200575.1

申请日：2013-04-26

申请人： Sirna Therapeutics, Inc.

发明人： Carr, Brian Allen ,  Jadhav, Vasant R. ,  Kenski, Denise M. ,  Tellers, David M. ,  Willingham, Aarron T.

IPC分类号： C12N15/113 ,  C12N15/11

摘要： The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity, and/or modulate a gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against target gene expression.

公开(公告)号：EP3358013A1

公开(公告)日：2018-08-08

申请号：EP17002009.3

申请日：2013-04-26

申请人： Sirna Therapeutics, Inc.

发明人： Carr, Brian Allen ,  Jadhav, Vasant R. ,  Kenski, Denise M. ,  Tellers, David M. ,  Willingham, Aarron T.

IPC分类号： C12N15/113 ,  C12N15/11

摘要： The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity, and/or modulate a gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against target gene expression.

公开(公告)号：EP3406730A1

公开(公告)日：2018-11-28

申请号：EP18182352.7

申请日：2011-08-29

申请人： Sirna Therapeutics, Inc.

发明人： Colletti, Steven L. ,  Gosselin, Francis ,  Jadhav, Vasant R. ,  Shaw, Anthony W. ,  Tellers, David M. ,  Tucker, Thomas J. ,  Yuan, Yu ,  Zewge, Daniel

IPC分类号： C12P21/06

CPC分类号： C12N15/113 ,  A61K47/64 ,  C12N15/111 ,  C12N15/87 ,  C12N2310/14 ,  C12N2310/3513 ,  C12N2310/3515 ,  C12N2320/32

摘要： In an embodiment the instant invention discloses a modular composition comprising 1) an oligonucleotide; 2) one or more linkers, which may be the same or different, selected from Table 1, wherein the linkers are attached to the oligonucleotide at the 2'-position of the ribose rings and/or the terminal 3'- and/or 5'-positions of the oligonucleotide; 3) optionally, one or more peptides, which may be the same or different, selected from SEQ ID NOs: 1-59, wherein the peptides are attached to the linkers; and optionally one or more lipids, solubilizing groups and/or targeting ligands attached to the oligonucleotide.

公开(公告)号：EP3358013B1

公开(公告)日：2020-06-24

申请号：EP17002009.3

申请日：2013-04-26

申请人： Sirna Therapeutics, Inc.

发明人： Carr, Brian Allen ,  Jadhav, Vasant R. ,  Kenski, Denise M. ,  Tellers, David M. ,  Willingham, Aarron T.

IPC分类号： C12N15/113 ,  C12N15/11