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    PREPARATION D'AMIDINES DERIVEES DE L'ACIDE 6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMANE-2-CARBOXYLIQUE
    3.
    发明授权
    PREPARATION D'AMIDINES DERIVEES DE L'ACIDE 6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMANE-2-CARBOXYLIQUE 有权

    公开(公告)号：EP1214309B8

    公开(公告)日：2004-07-14

    申请号：EP00960773.0

    申请日：2000-09-01

    申请人： Société de Conseils de Recherches et d'Applications Scientifiques ( S.C.R.A.S.)

    发明人： LE BRETON, Christine ,  MANGINOT, Eric ,  CAZAUX, Jean-Bernard

    IPC分类号： C07D311/66 ,  C07D409/12

    CPC分类号： C07D409/12 ,  C07D311/66

    摘要： The invention concerns the use of novel intermediates of general formula (II)B defined below for the synthesis of amidines derived from (-)-6-hydroxy-2,5,7,8 tetramethylchromane-2-carboxylic acid, such as for example, (S)-N-{4-[4-(3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)-carbonyl]-1-piperazinyl]phenyl}-2-thiophenecarboximidamide. In general formula (II)B: A' represents the radical (a), X represents -Z1-CO-; ς represents a bond or a heterocycle selected among the group consisting of piperidine, piperazine, homopiperazine, 2-methylpiperazine, 2,5-dimethyl-piperazine, 4-aminopiperidine radicals; Y represents a radical selected among the -Z2- and -NR3-Z2 radicals; R3 represents a hydrogen atom, a linear or branched alkyl radical with 1 to 6 carbon atoms or a -COR4 radical; R4 represents a linear or branched alkyl radical with 1 to 6 carbon atoms; Z1 and Z2 independently represent a single bond or a linear or branched alkyl radical with 1 to 6 carbon atoms; and R6 represents a hydrogen atom or a OH group.